Results 101 to 110 of about 521,864 (308)
Comparison of Regularization Methods in Fluorescence Molecular Tomography
Photonics, 2014 In vivo fluorescence molecular tomography (FMT) has been a popular functional imaging modality in research labs in the past two decades. One of the major difficulties of FMT lies in the ill-posed and ill-conditioned nature of the inverse problem in ...
Dianwen Zhu +4 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
, 2011 Ultrathin layered structures are known to act well as Bragg reflectors for light down to sub-nanometer wavelengths. However, the application of such structures in multi-element optics for photolithography at the wavelength of 13.5 nm has imposed ...
Bijkerk, Frederik
core
EnergiesLinear Fresnel reflectors are a versatile solar concentration technology, suitable for a wide range of industrial processes and thermal conditioning applications.
Alaric Christian Montenon +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
, 2017 We demonstrate how Fourier Nonlinear Optics elegantly merges the simplicity of linear optics with the power of conventional nonlinear optics to achieve the decoupling of frequencies, amplitudes and phases in nonlinear ...
Ibrahim H. +6 more
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Characterization of EUV induced contamination on multilayer optics [PDF]
, 2011 Extreme ultraviolet lithography (EUVL) is a next generation photolithographic technique that uses 13.5 nm or Extreme UV radiation and multilayer coated reflective optics.
Chen, J. Q., Chen, Juequan
core +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
EntropyFree-space optical (FSO) communication can be subject to various types of distortion and loss as the signal propagates through non-uniform media. In experiment and simulation, we demonstrate that the state of polarization and degree of polarization of ...
Nicholas Savino +5 more
doaj +1 more source