Results 111 to 120 of about 463,519 (308)
Grazing incidence neutron optics
, 2012 Neutron optics based on the two-reflection geometries are capable of controlling beams of long wavelength neutrons with low angular divergence. The preferred mirror fabrication technique is a replication process with electroform nickel replication ...
Engelhaupt, Darell E. +2 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Bottom–Up Metasurfaces for Biotechnological Applications
Advanced ScienceMetasurfaces are the 2D counterparts of metamaterials, and their development is accelerating rapidly in the past years. This progress enables the creation of devices capable of uniquely manipulating light, with applications ranging from optical ...
Francesca Petronella +4 more
doaj +1 more source
Modulation-assisted tunneling in laser-fabricated photonic Wannier–Stark ladders
New Journal of Physics, 2015 We observe Wannier–Stark (W–S) localization in curved photonic lattices, realized using arrays of evanescently coupled optical waveguides. By correctly tuning the strength of inter-site coupling in the lattice, we observe that W–S states become ...
Sebabrata Mukherjee +6 more
doaj +1 more source
, 2017 We demonstrate how Fourier Nonlinear Optics elegantly merges the simplicity of linear optics with the power of conventional nonlinear optics to achieve the decoupling of frequencies, amplitudes and phases in nonlinear ...
Ibrahim H. +6 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Conception and development of an adaptive optics testbed for free-space optical communication
, 2009 Optical free space communications are an efficient approach to transmit high data-rates with small antennas and low power consumption over large distances. Possible scenarios are links between satellites, up- and down-links from and to ground stations as
Moll, Florian
core
Self-imaging and caustics in two-dimensional surface plasmon optics [PDF]
, 2008 We study theoretically the surface plasmon electromagnetic field in the plane of the interface along which it propagates. Arbitrary Surface plasmon fields are expressed by a linear superposition of elementary surface plasmon modes, thus obtaining an ...
GABRIEL CONSTANTINO MARTINEZ NICONOFF +2 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source