Results 91 to 100 of about 494,314 (293)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
AHP in nonlinear scaling: from two-envelope problem to modeling by predictors [PDF]
ProductionPaper aims Extending the AHP abilities to new areas from explaining the famous Two-Envelope paradox to finding priorities as functions of auxiliary variables is suggested. Originality The proposed innovative and advantageous approach permits to find the
Stan Lipovetsky
doaj +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
AxiomsThis article introduces two enhanced techniques: the Natural Transform Iterative Method (NTIM) and the Optimal Auxiliary Function Method (OAFM). These approaches provide a close approximation for solving fractional-order Navier–Stokes equations, which ...
Siddiq Ur Rehman +3 more
doaj +1 more source
Optimal reform of safety circuit and upper computer in auxiliary shaft hoisting system
Gong-kuang zidonghua, 2014 In view of shortages in hardware and software of safety circuit and upper computer of coal mine auxiliary shaft hoisting system, optimal reform was applied to the system.
DU Ku
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Two-Phase Generalized Reduced Gradient Method for Constrained Global Optimization
Journal of Applied Mathematics, 2010 The random perturbation of generalized reduced gradient method for optimization under nonlinear differentiable constraints is proposed. Generally speaking, a particular iteration of this method proceeds in two phases.
Abdelkrim El Mouatasim
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Hole-Filling for DIBR Based on Depth and Gradient Information
International Journal of Advanced Robotic Systems, 2015 Depth image-based rendering (DIBR) is a method for generating new virtual images from known viewpoints. However, holes often appear in the rendered virtual images due to occlusion and inaccurate depth information.
Dan Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source