Results 81 to 90 of about 268,057 (260)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

AHP in nonlinear scaling: from two-envelope problem to modeling by predictors [PDF]

Production
Paper aims Extending the AHP abilities to new areas from explaining the famous Two-Envelope paradox to finding priorities as functions of auxiliary variables is suggested. Originality The proposed innovative and advantageous approach permits to find the
Stan Lipovetsky
doaj   +2 more sources

Measurement-based quantum control of mechanical motion

, 2018
Controlling a quantum system based on the observation of its dynamics is inevitably complicated by the backaction of the measurement process. Efficient measurements, however, maximize the amount of information gained per disturbance incurred.
A Kubanek, A Szorkovszky, A Vinante, AA Clerk, AC Doherty, AC Doherty, AC Doherty, Albert Schliesser, AM Jayich, B Abbott, C Genes, C Sayrin, D Kleckner, David Mason, DJ Wilson, DV Martynov, E Gavartin, ED Black, HM Wiseman, J Chan, J Thompson, J Zhang, J-M Courty, JB Clark, JD Teufel, JL Garbini, Junxin Chen, K Jacobs, KH Lee, M Aspelmeyer, M Gorodetksy, M Poggio, M Ringbauer, Massimiliano Rossi, MD LaHaye, NS Kampel, P Bushev, PF Cohadon, R Vijay, RW Peterson, S Mancini, S Schreppler, S Weis, SG Hofer, SG Hofer, T Li, TP Purdy, U Leonhardt, V Jain, VB Braginsky, W Wieczorek, WHP Nielsen, WP Bowen, Y Chu, Y Tsaturyan, Yeghishe Tsaturyan   +55 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Optimal reform of safety circuit and upper computer in auxiliary shaft hoisting system

Gong-kuang zidonghua, 2014
In view of shortages in hardware and software of safety circuit and upper computer of coal mine auxiliary shaft hoisting system, optimal reform was applied to the system.
DU Ku
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Closed-Form Almost Periodical Solutions for a Dynamical System Using the Optimal Auxiliary Functions Method

Mathematics
The main aim of our paper is concerning the damped oscillations of 3D dynamical systems, depending on a single physical parameter. This system does not admit Hamilton–Poisson structure but can be explicitly integrated, and the exact parametric solutions ...
Remus-Daniel Ene, Romeo Negrea, Rodica Badarau, Nicolina Pop   +3 more
doaj   +1 more source

Two-Phase Generalized Reduced Gradient Method for Constrained Global Optimization

Journal of Applied Mathematics, 2010
The random perturbation of generalized reduced gradient method for optimization under nonlinear differentiable constraints is proposed. Generally speaking, a particular iteration of this method proceeds in two phases.
Abdelkrim El Mouatasim
doaj   +1 more source