Results 91 to 100 of about 268,057 (260)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
AxiomsThis article introduces two enhanced techniques: the Natural Transform Iterative Method (NTIM) and the Optimal Auxiliary Function Method (OAFM). These approaches provide a close approximation for solving fractional-order Navier–Stokes equations, which ...
Siddiq Ur Rehman +3 more
doaj +1 more source
Hole-Filling for DIBR Based on Depth and Gradient Information
International Journal of Advanced Robotic Systems, 2015 Depth image-based rendering (DIBR) is a method for generating new virtual images from known viewpoints. However, holes often appear in the rendered virtual images due to occlusion and inaccurate depth information.
Dan Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Partial Differential Equations in Applied MathematicsThe study aims to obtain new approximate analytical solutions for the fractional order nonlinear Foam Drainage equation through a novel modification of the well-known Optimal Auxiliary Functions Method (OAFM). This method systematically constructs auxiliary functions, and by optimizing their parameters, it provides approximate solutions closely ...
Mimoon Ismael +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Advances in Difference Equations, 2018 In this paper, we consider a time-dependent diffusion problem with two-sided Riemann-Liouville fractional derivatives. By introducing a fractional-order flux as auxiliary variable, we establish the saddle-point variational formulation, based on which we ...
Qiong Yuan, Huanzhen Chen
doaj +1 more source