Results 111 to 120 of about 268,057 (260)

Novel solitonic structure, Hamiltonian dynamics and lie symmetry algebra of biofilm

Partial Differential Equations in Applied Mathematics
In this study, the Lie point symmetries and optimal system have been established. We discuss the biofilm model’s soliton solutions. To examine a nonlinear dynamical biofilm system, which is simply a bistable Allen–Cahn equation with quartic potential, to
Umair Asghar, Muhammad Imran Asjad, Waqas Ali Faridi, Ali Akgül   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Near-Optimal Tracking Control of a Nonholonomic Mobile Robot with Uncertainties

International Journal of Advanced Robotic Systems, 2012
A combined kinematic/torque control law is developed by using a backstepping design approach for a nonholonomic mobile robot with two driving wheels mounted on the same axis to track a reference trajectory.
Kai Wang
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The Optimal Auxiliary Functions Method for Semi-Analytical Solutions of the MHD Mixed Convection Stagnation-Point Flow Problem

Symmetry
The present paper treats the problem of steady laminar MHD flow of an incompressible viscous fluid for mixed convection stagnation-point flow over a vertical stretching sheet in the presence of an externally magnetic field. By means of the Optimal Auxiliary Functions Method (OAFM), the resulting nonlinear ODEs are semi-analytically solved.
Remus-Daniel Ene, Nicolina Pop, Rodica Badarau   +2 more
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Yardımcı fonksiyon yöntemini yönlü arama ile kullanarak yeni bir global optimizasyon tekniği ve bilgisayar uygulamaları = New global optimization technique by using auxiliary function method in directional search with computer applications /

, 2021
Tez (Doktora) - Süleyman Demirel Üniversitesi, Fen Bilimleri Enstitüsü, Matematik Anabilim Dalı, 2020.
Ibrahem, Shehab Ahmed Ibrahem, 1979- author 212556, Şahiner, Ahmet, 1970- thesis advisor 15279, Süleyman Demirel Üniversitesi. Fen Bilimleri Enstitüsü. Matematik Anabilim Dalı. 10117 issuing body   +2 more
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source