Results 91 to 100 of about 12,436,371 (298)

Optimal control problem for the impulsive differential equations with non-local boundary conditions

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2013
The optimal control problem is investigated, where the state of the controlled system is described by the impulsive differential equations with non-local boundary conditions.
Yagub A Sharifov
doaj   +1 more source

A Stochastic Optimal Control Problem for the Heat Equation on the Halfline with Dirichlet Boundary-Noise and Boundary-Control [PDF]

Applied Mathematics & Optimization, 2010
We consider a controlled state equation of parabolic type on the halfline $(0,+\infty)$ with boundary conditions of Dirichlet type in which the unknown is equal to the sum of the control and of a white noise in time. We study finite horizon and infinite horizon optimal control problem related by menas of backward stochastic differential equations.
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inverse Optimality of Regulation Design for Korteweg-De Vries-Burgers Equation

IEEE Access
In optimal control, it is often necessary to solve Hamilton-Jacobi-Isaacs (HJI) partial differential equation, but it is not only difficult to solve, sometimes even impossible to solve.
Xiushan Cai, Cong Lin
doaj   +1 more source

Optimal boundary control of a tracking problem for a parabolic distributed system with open-loop control using evolutionary algorithms [PDF]

Journal of Systemics, Cybernetics and Informatics, 2003
In this paper we examine the application of evolutionary algorithms to find open-loop control solutions of the optimal control problem arising from the semidiscretisation of a linear parabolic tracking problem with boundary control.
Russel J Stonier, Michael J Drumm
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis and optimal boundary control of a nonstandard system of phase field equations [PDF]

, 2012
We investigate a nonstandard phase field model of Cahn-Hilliard type. The model, which was introduced in Podio-Guidugli (2006), describes two-species phase segregation and consists of a system of two highly nonlinearly coupled PDEs.
Gilardi, Gianni, Gillardi, Gianni, Sprekels, Jürgen, Colli, Pierluigi   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pulse and Point Optimal Control of Linear Hyperbolic Integro-Differential Systems with Mixed Boundary Conditions

Journal of Optimization, Differential Equations and Their Applications
We investigate an optimal control problem for a linear hyperbolic integrodifferential equation, subject to Robin-type boundary conditions. The control operates as an operator on the equation’s right-hand side, integrating Dirac delta functions concerning
Andrii V. Anikushyn
doaj   +1 more source