Results 101 to 110 of about 12,436,371 (298)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2009 Optimal control problems with delays in state and control variables are studied. Constraints are imposed as mixed control–state inequality constraints. Necessary optimality conditions in the form of Pontryagin's minimum principle are established.
Göllmann, Laurenz +2 more
core +1 more source
The Structure of the Optimal Control in the Problems of Strength Optimization of Steel Girders
Archives of Civil Engineering, 2019 The paper concerns a strength optimization of continuous beams with variable cross-section. The continuous beams are subjected to a dead weight and a useful load, the six (seven) combinations of loads were analyzed.
Mikulski Leszek
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Linear Operator Inequality and Null Controllability with Vanishing Energy for Unbounded Control Systems [PDF]
, 2013 We consider a linear boundary or point control system on a Hilbert space $H$ which is null controllable at some time $T_0 >0$. To every initial state $ y_0 \in H$ we associate the minimal ``energy'' needed to transfer $ y_0 $ to $ 0 $ in a time $ T \ge ...
Zabczyk, J. +7 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Optimal investment models with vintage capital: Dynamic Programming approach [PDF]
The Dynamic Programming approach for a family of optimal investment models with vintage capital is here developed. The problem falls into the class of infinite horizon optimal control problems of PDE's with age structure that have been studied in various
Silvia Faggian, Fausto Gozzi
core
Nonlinear optimal perturbations in a Couette flow: bursting and transition [PDF]
, 2013 This paper provides the analysis of bursting and transition to turbulence in a Couette flow, based on the growth of nonlinear optimal disturbances. We use a global variational procedure to identify such optimal disturbances, defined as those initial ...
DE PALMA, Pietro, CHERUBINI, Stefania
core +1 more source
Optimal Control Systems by Time-Dependent Coefficients Using CAS Wavelets
Journal of Applied Mathematics, 2009 This paper considers the problem of controlling the solution of an initial boundary-value problem for a wave equation with time-dependent sound speed. The control problem is to determine the optimal sound speed function which damps the vibration of the ...
Taher Abualrub +2 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source