Results 71 to 80 of about 3,101,275 (254)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Decoding Algorithm for LDPC Codes Over Erasure Channels with Sporadic Errors [PDF]

, 2010
An efficient decoding algorithm for low-density parity-check (LDPC) codes on erasure channels with sporadic errors (i.e., binary error-and-erasure channels with error probability much smaller than the erasure probability) is proposed and its performance ...
Paolini, Enrico, G. Liva, Balazs Matuz, B. Matuz, Marco Chiani, Liva, Gianluigi, Chiani, Marco, Matuz, Balazs, Gianluigi Liva, Enrico Paolini   +9 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A Study of F_qR-Cyclic Codes and Their Applications in Constructing Quantum Codes

IEEE Access, 2020
Let R = Fq + uFq + vFq + uvFq, with u2 = u, v2 = v, uv = vu, where q = pm for a positive integer m and an odd prime p. We study the algebraic structure of FqR-cyclic codes of block length (r, s). These codes can be viewed as R[x]-submodules of Fq[x]/(xr -
Hai Q. Dinh, Sachin Pathak, Tushar Bag, Ashish Kumar Upadhyay, Warattaya Chinnakum   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Concatenated Turbo/LDPC codes for deep space communications: performance and implementation [PDF]

, 2013
Deep space communications require error correction codes able to reach extremely low bit-error-rates, possibly with a steep waterfall region and without error floor. Several schemes have been proposed in the literature to achieve these goals.
Condo, Carlo
core  

Low‐complexity near‐optimal detection of dc2‐balanced codes

Electronics Letters, 2016
Two constructions of a low‐complexity near‐optimal detection method of dc2‐balanced codes are presented. The methods presented are improvements on Slepian's algorithm for optimal detection of permutation codes.
K.A.S. Immink
doaj   +1 more source