Results 81 to 90 of about 3,101,275 (254)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

بهینه‌سازی کدهای دودویی

علوم رایانش و فناوری اطلاعات, 2021
All binary codes, even Huffman optimal code, are kind of non-optimal bit arrangement. Therefore, binary code optimization is a challenging problem. In this paper an algorithm is proposed to optimize the codes by converting any type of binary code to a ...
پرویز قره باقری, سید حمید حاج سید جوادی, پروانه اصغری   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reliable multicast transport by satellite: a hybrid satellite/terrestrial solution with erasure codes [PDF]

, 2004
Geostationary satellites are an efficient way to provide a large scale multipoint communication service. In the context of reliable multicast communications, a new hybrid satellite/terrestrial approach is proposed.
L. Dairaine, J. Lacan, Fraboul, Christian, Dairaine, Laurent, Lacan, Jérôme, Florestan de Belleville, Laurent Dairaine, F. De Belleville, Christian Fraboul, De Belleville, Florestan, C. Fraboul, Jérôme Lacan   +11 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Comparative Study of Turbo Equalization Schemes using Convolutional, Convolutional Turbo, and Block-Turbo Codes

, 2002
Turbo equalizers have been shown to be successful in mitigating the effects of inter-symbol interference introduced by partial response modems and by dispersive channels for code rates of $R \le 1/2$.
Hamorsky, J., Yeap, B.L., Liew, T.H., Hanzo, L.   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

On optimal and near-optimal turbo decoding using generalized max operator [PDF]

, 2009
Motivated by a recently published robust geometric programming approximation, a generalized approach for approximating efficiently the max* operator is presented.
PAPAHARALABOS S, MATHIOPOULOS P. T, Mathiopoulos P.T, Papaharalabos, S., Masera, Guido, Martina, Maurizio   +5 more
core   +1 more source

Comments on “Optimal Dual Frames of Probabilistic Erasures”

IEEE Access
In Li et al., the authors claim uniqueness of the canonical dual as the 1−erasure probabilistic optimal dual under certain conditions. We provide counterexamples and showed that these conditions are insufficient and we correct the main theorem ...
Shankhadeep Mondal, Ram Narayan Mohapatra   +1 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source