Results 41 to 50 of about 3,665,900 (304)

On Attainability of Optimal Solutions for Linear Elliptic Equations with Unbounded Coefficients

Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Modelûvannâ, 2011
We study an optimal boundary control problem (OCP) associated to a linear elliptic equation —div (Vj/ + A(x)Vy) = f describing diffusion in a turbulent flow. The characteristic feature of this equation is the fact that, in applications, the stream matrix
P. I. Kogut, O. P. Kupenko
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Optimizing the Coefficients of Numerical Differentiation Formulae Using Neural Networks

IEEE Access, 2021
The use of a numerical differentiation formula (NDF) is an excellent method for solving stiff ordinary differential equations. However, the NDF method cannot fully adapt to all stiff systems.
Xinyu Yang, Lei Zhang, Yuan Yuan, Zhiqi Zhao   +3 more
doaj   +1 more source

On Optimization of Power Coefficient of HAWT

Journal of Power and Energy Engineering, 2014
The horizontal axis wind turbine (HAWT) blades rotation in the steady wind flow is considered. We discuss the problem of determining the blade twist which could guarantee the maximum value of the power coefficient. We define the blade twist as the technological turn of sections of blade around its axis.
Marat Z. Dosaev, Lyubov A. Klimina, Boris Ya. Lokshin, Yury D. Selyutskiy, Shih-Shin Hwang   +4 more
openaire   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

ON APPROXIMATION OF STATE-CONSTRAINED OPTIMAL CONTROL PROBLEM IN COEFFICIENTS FOR p-BIHARMONIC EQUATION

Journal of Optimization, Differential Equations and Their Applications, 2018
We study a Dirichlet-Navier optimal design problem for a quasi-linear mono- tone p-biharmonic equation with control and state constraints. The coecient of the p-biharmonic operator we take as a design variable in BV ( )\L1( ).
Peter I. Kogut, Olha P. Kupenko
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Optimal Control in Coefficients for Degenerate Linear Parabolic Equations

, 2014
The aim of this work is to study the optimal control problem associated to a linear parabolic equation with homogeneous Dirichlet boundary condition. The control variable is the matrix of L1-coefficients in the main part of the parabolic operator. The
I. G. Balanenko, MANZO, Rosanna
core   +1 more source

mploying Virial Coefficients for Optimal Solutions in Variational Calculations

Cumhuriyet Science Journal
In this study, virial coefficients for one and two-electron hydrogen and helium-like quantum dot structures confined in an infinite potential well were calculated.
Mahmut Özgür Sezer
doaj   +1 more source