Results 51 to 60 of about 3,665,900 (304)

Optimal control with adaptive weighting coefficients for integrated vehicle dynamics control [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2014
: In this work, an optimal control scheme with adaptive weighting coefficients is presented which coordinates different vehicle dynamics control objectives, thus ruling out possible conflicts among them.
naser esmaeili, S. Hamed Tabatabaei Oreh, Reza Kazemi   +2 more
doaj  

On relaxation of state-constrained optimal control problem in coefficients for biharmonic equation

Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Modelûvannâ, 2015
We study a Dirichlet optimal control problem for biharmonic equation withcontrol and state constraints. The coecient of the biharmonic operator, the weightu, we take as a control in L1(Ω).
P. I. Kogut, L. V. Voloshko
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

On an Optimal -Control Problem in Coefficients for Linear Elliptic Variational Inequality

Abstract and Applied Analysis, 2013
We consider optimal control problems for linear degenerate elliptic variational inequalities with homogeneous Dirichlet boundary conditions. We take the matrix-valued coefficients in the main part of the elliptic operator as controls in .
Olha P. Kupenko, Rosanna Manzo
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Fractional optimal control problems with trajectory-dependent singular coefficients

Journal of Inequalities and Applications
We investigate a class of fractional optimal control problems governed by semilinear fractional differential equations with trajectory-dependent singular coefficients. The state equation is formulated using the Caputo fractional derivative and contains a
G. M. Bahaa, A. H. Qamlo
doaj   +1 more source

Optimal Selection of Wavelet Coefficients for Electrocardiograph Compression [PDF]

ETRI Journal, 2007
This paper presents a simple method to implement a complete on-line portable wireless holter including an electrocardiogram (ECG) monitoring, processing, and communication protocol. The proposed algorithm significantly reduces the hardware resources of threshold estimation for ECG compression, using the standard deviation updated with each new input ...
Quero Reboul, José Manuel, Elena Pérez, María del Mar, Borrego, Inmaculada   +2 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source