Results 141 to 150 of about 1,591,625 (316)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Noise load management at Amsterdam Airport Schiphol [PDF]
, 2007 Amsterdam Airport Schiphol is one of the five primary hub-airports in Europe. All flight movements are controlled by Air Traffic Control the Netherlands (LVNL), whose main objective is to guarantee safety, efficiency, and protection of the environment ...
Boucherie, R.J. +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
, 2021 The main objective of this thesis is to contribute to selective maintenance optimization's strategies for complex mission-oriented systems. Selective maintenance is a maintenance strategy designed for specific multi-component systems operating a series of alternating missions and scheduled breaks.
openaire +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
A Theory of Noncontributory Pension Design [PDF]
Noncontributory subsidies for the old poor (first-pillar pensions) affect the welfare of hundreds of millions around the world. Their benevolent rationale is to redistribute progressively, subject to efficiency considerations.
Salvador Valdés
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Accelerating scientific codes by performance and accuracy modeling
, 2016 Scientific software is often driven by multiple parameters that affect both accuracy and performance. Since finding the optimal configuration of these parameters is a highly complex task, it extremely common that the software is used suboptimally.
Bientinesi, Paolo +2 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Pavement compactness estimation based on 3D pavement texture features
Case Studies in Construction MaterialsUnderstanding the correlation between pavement compactness and pavement texture features aids in determining the range of compaction passes. This paper proposes an estimation model for pavement compactness based on 3D pavement features.
Shengchuan Jiang +5 more
doaj +1 more source