Results 131 to 140 of about 1,591,625 (316)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Evaluating the impact of uncertainty in estimated breeding values on optimal contribution selection
, 2023 Many livestock breeding programmes have a closed nucleus and therefore have to manage the conversion of genetic variation into genetic gain with care. Consequently, these breeding programmes use some methods for managing genetic variation. One such method is the optimal contribution selection (OCS), which aims to maximise genetic gain for a given loss ...
Pocrnic, Ivan +2 more
openaire +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Regressive intracohort redistribution in nonfinancial defined contribution pension [PDF]
, 2013 Nonfinancial defined contribution (NDC) pension systems have recently become popular because they provide the strong incentives of the private funded systems without requiring a difficult transition period.
Simonovits, András
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Interference Management in Heterogeneous Networks with Blind Transmitters
, 2016 Future multi-tier communication networks will require enhanced network capacity and reduced overhead. In the absence of Channel State Information (CSI) at the transmitters, Blind Interference Alignment (BIA) and Topological Interference Management (TIM ...
Johnson, Oliver +2 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Pattern Recognition Methods and Features Selection for Speech Emotion Recognition System
The Scientific World Journal, 2015 The impact of the classification method and features selection for the speech emotion recognition accuracy is discussed in this paper. Selecting the correct parameters in combination with the classifier is an important part of reducing the complexity of ...
Pavol Partila +2 more
doaj +1 more source