Results 111 to 120 of about 1,591,625 (316)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Energy Harvesting Cooperative Networks: Is the Max-Min Criterion Still Diversity-Optimal?
, 2014 This paper considers a general energy harvesting cooperative network with M source-destination (SD) pairs and one relay, where the relay schedules only m user pairs for transmissions.
Ding, Zhiguo, Poor, H. Vincent
core
Ensemble feature selection for high-dimensional data: a stability analysis across multiple domains
Neural computing & applications (Print), 2019 Selecting a subset of relevant features is crucial to the analysis of high-dimensional datasets coming from a number of application domains, such as biomedical data, document and image analysis.
B. Pes
semanticscholar +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Emerging Market Pension Funds and International Diversification [PDF]
Many countries are currently increasing the advanced funding of their public pension systems to improve their sustainability in the face of rapidly aging populations. When pensions are funded, the issue of asset allocation becomes of paramount importance.
Pfau, Wade Donald
core +1 more source
Annals of Surgical Oncology, 2017 The optimal treatment sequence for patients with advanced rectal cancer and synchronous resectable liver metastases is controversial. We examined the outcomes associated with an individualized selection of classic, reversed, or combined approaches.Between 1999 and 2014, 268 patients with rectal cancer and synchronous liver-only metastases underwent ...
Claudius, Conrad +10 more
openaire +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
MedVoxelHD: Improved CUDA-accelerated morphological Hausdorff distances in medical image analysis
SoftwareXThe selection of optimal segmentation metrics is a critical aspect in the development of successful algorithms. According to new research, average Hausdorff distance (HD) should be the primary metric that evaluates contour alignment.
Jakub Mitura +2 more
doaj +1 more source
Contract Design to Sequester Carbon in Agricultural Soils [PDF]
According to several studies, agricultural carbon sequestration could be a relatively low cost opportunity to mitigate greenhouse gas (GHG) concentration and a promising means that could be institutionalised.
Mireille Chiroleu-Assouline +1 more
core
General Equilibrium with Asymmetric Information: A Dual Approach [PDF]
, 2000 We study markets where the characteristics or decisions of certain agents are relevant but not known to their trading partners. Assuming exclusive trans- actions, the environment is described as a continuum economy with indivis- ible commodities.
Jerez, Belén
core +1 more source