Results 101 to 110 of about 1,879,077 (319)

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

open access: yesMolecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park   +6 more
wiley   +1 more source

A Quasi Time Optimal Receding Horizon Control [PDF]

open access: yesarXiv, 2007
This paper presents a quasi time optimal receding horizon control algorithm. The proposed algorithm generates near time optimal control when the state of the system is far from the target. When the state attains a certain neighbourhood of the aim, it begins the adaptation of the cost function.
arxiv  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Optimal Modal Control

open access: yesMeasurement + Control, 1973
In this paper, optimal and modal control theories are combined to form a new theory of optimal modal control. This theory provides a rational basis for the selection of a modal state weighting matrix which ensures that the plant matrix of the resulting ...
M. A. Woodhead, B. Porter
doaj   +1 more source

Limit theory for controlled McKean-Vlasov dynamics [PDF]

open access: yesarXiv, 2016
This paper rigorously connects the problem of optimal control of McKean-Vlasov dynamics with large systems of interacting controlled state processes. Precisely, the empirical distributions of near-optimal control-state pairs for the $n$-state systems, as $n$ tends to infinity, admit limit points in distribution (if the objective functions are suitably ...
arxiv  

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Optimal Synchronization Control for Heterogeneous Multi-Agent Systems: Online Adaptive Learning Solutions [PDF]

open access: yesarXiv, 2020
This paper presents an online adaptive learning solution to optimal synchronization control problem of heterogeneous multi-agent systems via a novel distributed policy iteration approach.
arxiv  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Minimum-Time Frictionless Atom Cooling in Harmonic Traps [PDF]

open access: yesSIAM J. Control Optim., Vol. 49, pp. 2440-2462, 2011, 2010
Frictionless atom cooling in harmonic traps is formulated as a time-optimal control problem and a synthesis of optimal controlled trajectories is obtained.
arxiv  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

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