Results 41 to 50 of about 430,579 (268)

Morse Families In Optimal Control Problems [PDF]

open access: yesSIAM Journal on Control and Optimization, 2015
We geometrically describe optimal control problems in terms of Morse families in the Hamiltonian framework. These geometric structures allow us to recover the classical first order necessary conditions for optimality and the starting point to run an integrability algorithm.
María Barbero-Liñán   +2 more
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Problem of optimal control system synthesis

open access: yesRUDN Journal of Engineering Research, 2008
Problem of control system synthesis is considered, when control depends from state space vector. Analytic and calculation problems of synthesis and paths for decision of them are focused.
A I Diveev
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Optimal Control of the Ill-Posed Cauchy Elliptic Problem

open access: yesInternational Journal of Differential Equations, 2015
We give a characterization of the control for ill-posed problems of oscillating solutions. More precisely, we study the control of Cauchy elliptic problems via a regularization approach which generates incomplete information.
A. Berhail, A. Omrane
doaj   +1 more source

Time-optimal control problem with two final points for a kinematic model of an UAV

open access: yesVisnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika, 2019
We study the time-optimal control problem for an unmanned aerial vehicle (drone) moving in the plane of a constant altitude. A kinematic model is considered where the angular velocity is a control. Such a system is described by Markov-Dubins equations; a
Svetlana Yu. Ignatovich   +1 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Time-optimal controlonasubspaceforthetwoand three-dimensional system

open access: yesVisnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika
This article is devoted to the problem of the optimal synthesis on a subspace for the 2 and 3-dimensional case for the linear control system $\dot{x_1} = u, \dot{x}_i=x_{i-1}, i=\overline{2,n}$ with $|u|\le1$.
Oleh Vozniak, Valery Korobov
doaj   +1 more source

Optimal Control Approach to Lambert’s Problem and Gibbs’ Method

open access: yesApplied Sciences, 2020
This paper presents the optimal control approach to solve both Lambert’s problem and Gibbs’ method, which are commonly used for preliminary orbit determination.
Minjeong Kim, Sungsu Park
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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