Results 41 to 50 of about 2,306,950 (285)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Time-optimal control problem with two final points for a kinematic model of an UAV
Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika, 2019 We study the time-optimal control problem for an unmanned aerial vehicle (drone) moving in the plane of a constant altitude. A kinematic model is considered where the angular velocity is a control. Such a system is described by Markov-Dubins equations; a
Svetlana Yu. Ignatovich +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
An optimal control problem without control costs
Mathematical Biosciences and Engineering, 2023 <abstract><p>A two-dimensional diffusion process is controlled until it enters a given subset of $ \mathbb{R}^2 $. The aim is to find the control that minimizes the expected value of a cost function in which there are no control costs. The optimal control can be expressed in terms of the value function, which gives the smallest value that ...
openaire +4 more sources
Optimal Control of the Ill-Posed Cauchy Elliptic Problem
International Journal of Differential Equations, 2015 We give a characterization of the control for ill-posed problems of oscillating solutions. More precisely, we study the control of Cauchy elliptic problems via a regularization approach which generates incomplete information.
A. Berhail, A. Omrane
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Optimal Control Problem for Cholera Disease and Cost-Effectiveness Analysis
Journal of Mathematical and Fundamental Sciences, 2021 Cholera is a disease that continues to be a threat to public health globally and is an indicator of inequity and lack of social development in countries. For this reason, strategies for its control need to be investigated.
Jhoana Patricia Romero-Leiton +2 more
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Problem of optimal control system synthesis
RUDN Journal of Engineering Research, 2008 Problem of control system synthesis is considered, when control depends from state space vector. Analytic and calculation problems of synthesis and paths for decision of them are focused.
A I Diveev
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source