Results 51 to 60 of about 16,385,685 (296)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Problem of optimal control system synthesis
RUDN Journal of Engineering Research, 2008 Problem of control system synthesis is considered, when control depends from state space vector. Analytic and calculation problems of synthesis and paths for decision of them are focused.
A I Diveev
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Optimal Control of the Ill-Posed Cauchy Elliptic Problem
International Journal of Differential Equations, 2015 We give a characterization of the control for ill-posed problems of oscillating solutions. More precisely, we study the control of Cauchy elliptic problems via a regularization approach which generates incomplete information.
A. Berhail, A. Omrane
doaj +1 more source
Time-optimal control problem with two final points for a kinematic model of an UAV
Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika, 2019 We study the time-optimal control problem for an unmanned aerial vehicle (drone) moving in the plane of a constant altitude. A kinematic model is considered where the angular velocity is a control. Such a system is described by Markov-Dubins equations; a
Svetlana Yu. Ignatovich +1 more
doaj +1 more source
An optimal control problem for single-spot pulsed laser welding
Journal of Mathematics in Industry, 2023 We consider an optimal control problem for a single-spot pulsed laser welding problem. The distribution of thermal energy is described by a quasilinear heat equation.
Roland Herzog, Dmytro Strelnikov
doaj +1 more source
Morse Families In Optimal Control Problems [PDF]
SIAM Journal on Control and Optimization, 2015 We geometrically describe optimal control problems in terms of Morse families in the Hamiltonian framework. These geometric structures allow us to recover the classical first order necessary conditions for optimality and the starting point to run an integrability algorithm.
María Barbero-Liñán +2 more
openaire +4 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Time-optimal controlonasubspaceforthetwoand three-dimensional system
Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i MehanikaThis article is devoted to the problem of the optimal synthesis on a subspace for the 2 and 3-dimensional case for the linear control system $\dot{x_1} = u, \dot{x}_i=x_{i-1}, i=\overline{2,n}$ with $|u|\le1$.
Oleh Vozniak, Valery Korobov
doaj +1 more source