Results 31 to 40 of about 376,459 (265)

Novel Spreadsheet Direct Method for Optimal Control Problems

Mathematical and Computational Applications, 2018
We devise a simple yet highly effective technique for solving general optimal control problems in Excel spreadsheets. The technique exploits Excel’s native nonlinear programming (NLP) Solver Command, in conjunction with two calculus worksheet functions ...
Chahid Kamel Ghaddar
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

ON THE LOCAL CONTROLLABILITY FOR OPTIMAL CONTROL PROBLEMS

Matematički Vesnik
The authors consider the control system: \(\overset{.}{x}=f(x,u,t)\), \( x(t_{0})=x_{0}\), \(u(t)\in U(t)\), \(t\in \lbrack t_{0},t_{1}]\), where \(t\) is the time, \(x\in \mathbb{R}^{n}\) a state variable, \(x_{0}\) is fixed, and the control \(u(t)\in U(t)\) for a.a. \(t\in \lbrack t_{0},t_{1}]\). The set-valued mapping \(U:\mathbb{R}\rightrightarrows
Arutyunov, A. V., Zhukovskiy, S. E.
openaire   +2 more sources

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Optimal Control Problems for Nonlinear Variational Evolution Inequalities

Abstract and Applied Analysis, 2013
We deal with optimal control problems governed by semilinear parabolic type equations and in particular described by variational inequalities. We will also characterize the optimal controls by giving necessary conditions for optimality by proving the ...
Eun-Young Ju, Jin-Mun Jeong
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Optimal Control Problems for Erlang Loss Systems

Axioms
An Erlang loss system, which is an M/G/s/s queue, is a model used in various applications. In this paper, a controlled version of the process is defined.
Mario Lefebvre
doaj   +1 more source

Morse Families In Optimal Control Problems [PDF]

SIAM Journal on Control and Optimization, 2015
We geometrically describe optimal control problems in terms of Morse families in the Hamiltonian framework. These geometric structures allow us to recover the classical first order necessary conditions for optimality and the starting point to run an integrability algorithm.
María Barbero-Liñán, David Iglesias Ponte, David Martín de Diego   +2 more
openaire   +3 more sources