Results 51 to 60 of about 376,459 (265)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Some optimal control problems for partial differential inclusions [PDF]
Opuscula Mathematica, 2008 Partial differential inclusions are considered. In particular, basing on diffusions properties of weak solutions to stochastic differential inclusions, some existence theorems and some properties of solutions to partial differential inclusions are given.
Michał Kisielewicz
doaj
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Solution of an Optimal Control Problem with Mathcad
International Journal of Geology, 2015 The paper deals with optimal control problems whose behavior is described by an elliptic equations with Bitsadze– Samarski nonlocal boundary conditions. The theorem about a necessary and sufficient optimality condition is given. The existence and uniqueness of a solution of the conjugate problem are proved.
David Devadze +2 more
openaire +1 more source
Adaptive optimal control of Signorini’s problem [PDF]
Computational Optimization and Applications, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Andreas Rademacher, Korinna Rosin
openaire +2 more sources
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Suppressing ineffective control actions in optimal power flow problems
IET Generation, Transmission & Distribution, 2020 Many utilities are still reluctant in adopting optimal power flow (OPF) tools for decision‐making in operation. This paper scrutinizes this issue from the perspective of whether all control actions proposed by an OPF are truly effective to an operator ...
Florin Capitanescu
doaj +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Mathematical Modelling and Analysis, 2013 In this paper, a Piecewise Adomian Decomposition Method (PADM) is used to obtain the analytical approximate solution for a class of infinite horizon nonlinear optimal control problems (OCPs). The method is a new modification of the standard ADM, in which
Hassan Saberi Nik +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source