Results 41 to 50 of about 376,459 (265)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
GPU-Accelerated Pseudospectral Methods for Optimal Control Problems
MathematicsPseudospectral methods are effective tools for solving optimal control problems, but they result in large-scale nonlinear programming (NLP) problems that are computationally demanding.
Yilin Zou, Fanghua Jiang
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QuITO: Numerical software for constrained nonlinear optimal control problems
SoftwareX, 2023 We introduce the MATLAB-based software QuITO (Quasi-Interpolation based Trajectory Optimization) to numerically solve a wide class of constrained nonlinear optimal control problems (OCP). The solver is based on the QuITO (the same abbreviation) algorithm,
Siddhartha Ganguly +4 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Abnormality and Strict-Sense Minimizers That Are Not Extended Minimizers
MathematicsWe consider a constrained optimal control problem and an extension of it, in which the set of strict-sense trajectories is enlarged. Extension is a common procedure in optimal control used to derive necessary and sufficient optimality conditions for the ...
Giovanni Fusco, Monica Motta
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Optimal control problems on the co-adjoint Lie groupoids [PDF]
Archives of Control SciencesIn this work we study the invariant optimal control problem on Lie groupoids.We show that any invariant optimal control problem on a Lie groupoid reduces to its co-adjoint Lie algebroid.
Ghorbanali Haghighatdoost
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Automatika, 2020 This paper presents a Laguerre homotopy method for quadratic optimal control problems in semi-infinite intervals (LaHOC), with particular interests given to nonlinear interconnected large-scale dynamic systems.
Mojtaba Masoumnezhad +3 more
doaj +1 more source