Results 101 to 110 of about 4,114,836 (337)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Which Optimal Design For LLDAs? [PDF]

Lottery-linked deposit accounts are financial assets that provide an interest rate determined by a lottery. The aim of this study is to determine the optimal design of these financial assets (under cumulative prospect theory (CPT) framework).
Marie Pfiffelmann
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Optimal design of solidification processes [PDF]

An optimal design algorithm is presented for the analysis of general solidification processes, and is demonstrated for the growth of GaAs crystals in a Bridgman furnace. The system is optimal in the sense that the prespecified temperature distribution in
Dantzig, Jonathan A., Tortorelli, Daniel A.   +1 more
core   +1 more source

Optimized is Not Always Optimal - The Dilemma of Analog Design Automation [PDF]

, 2022
Jürgen Scheible
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

2D Mutation-Based Elitist Genetic Algorithm for Optimal Design of Transmissive Linear-to-Circular Polarization Conversion Metasurfaces

Applied Sciences
Although the elitist genetic algorithm (EGA) is an approach for the optimal design of pixelated metasurfaces, it is necessary to convert a two-dimensional (2D) metasurface to a one-dimensional array.
Jiao Wang, Wanguang Xiong, Hongkai Zhou, Chao Xu, Yannan Jiang   +4 more
doaj   +1 more source

Optimal Design of Fractional-Order PID Controllers for a Nonlinear AWS Wave Energy Converter Using Hybrid Jellyfish Search and Particle Swarm Optimization [PDF]

, 2023
Ziad M. Ali, Ahmed Mahdy, Hany M. Hasanien, Shady H. E. Abdel Aleem   +3 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adaptive Design of Solar-Powered Energy Systems Based on Daily Clearness State Evolution

Energies
The optimal designing of the hybrid energy system (HES) is a challenging task due to the multiple objectives and various uncertainties. Especially for HES, primarily powered by solar energy, the reference solar radiation data directly impact the result ...
Dong Liang, Long Ma, Peng Wang, Yuanxia Li, Yiping Luo   +4 more
doaj   +1 more source