Results 101 to 110 of about 4,071,178 (286)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Structure Analysis and Heat Transfer Performance Study on Spiral Plate of the Adsorption Bed
Zhileng xuebao, 2013 The advantages and disadvantages of the spiral plate adsorption bed are analyzed. The heat transfer process and the demand of cold and heat sources in a spiral plate adsorption bed, which is designed with counter-flow heat transfer and based on 15kW ...
Chen Huanxin +6 more
doaj
Development and Characteristic Test of Downhole Alternating Flow Field ROP Enhancing Tool
Shiyou jixie, 2020 Existing pulse jet tools have the problems of large pulse intensity loss and inferior ROP enhancement performance. To address the problem, a new type of downhole alternating flow field ROP enhancing tool is developed.
Fan Jiqiang
doaj
Optimal policy design for the sugar tax
, 2018 Healthy nutrition promotions and regulations have long been regarded as a tool for increasing social welfare. One of the avenues taken in the past decade is sugar consumption regulation by introducing a sugar tax.
Geyskens, Kelly +3 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A Multi-Objective PFC Boost Inductor Optimal Design Algorithm Based on Pareto Front
EnergiesIn this study, the inductor optimization design is performed by applying the Pareto optimization technique. As environmental problems emerge, the electric vehicle market is expanding, and accordingly, volume reduction and high efficiency of the onboard ...
Ye-Ji Hyeon +3 more
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Adaptive Exploration Artificial Bee Colony for Mathematical Optimization
AIThe artificial bee colony (ABC) algorithm is a famous swarm intelligence method utilized across various disciplines due to its robustness. However, it exhibits limitations in exploration mechanisms, particularly in high-dimensional or complex landscapes.
Shaymaa Alsamia +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source