Results 31 to 40 of about 14,243,831 (247)

A New Perspective on the Convergence of Mean-Based Methods for Nonlinear Equations

Mathematics
Many problems in science, engineering, and economics require solving of nonlinear equations, often arising from attempts to model natural systems and predict their behavior.
Alicia Cordero, María Emilia Maldonado Machuca, Juan R. Torregrosa   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Iterative thresholding for sparse approximations [PDF]

, 2008
Sparse signal expansions represent or approximate a signal using a small number of elements from a large collection of elementary waveforms. Finding the optimal sparse expansion is known to be NP hard in general and non-optimal strategies such as ...
Blumensath, T., Davies, Mike E., Blumensath, Thomas, Davies, Michael; id_orcid   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Constrained optimal control theory for differential linear repetitive processes

, 2008
Differential repetitive processes are a distinct class of continuous-discrete two-dimensional linear systems of both systems theoretic and applications interest.
Eric Rogers, Rogers, E., Krzysztof Galkowski, Dymkou, S., Galkowski, K., Dymkov, M., Michael Dymkov, Siarhei Dymkou   +7 more
core   +1 more source

Optimal Derivative-Free Root Finding Methods Based on Inverse Interpolation

Mathematics, 2019
Finding a simple root for a nonlinear equation f ( x ) = 0 , f : I ⊆ R → R has always been of much interest due to its wide applications in many fields of science and engineering.
Moin-ud-Din Junjua, Fiza Zafar, Nusrat Yasmin   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Precoded Sphere Packing Aided Bit-Interleaved Differential Spa ce-Time Coded Modulation Using Iterative Decoding [PDF]

, 2008
—In this treatise, we investigate a precoded and sphere packing (SP)-aided bit-interleaved differential space-time coded modulation scheme using iterative decoding. The amalgamated design and interworking of the SP, differential encoding, and iteratively
Alamri, Osamah, Ng, Soon, Wu, Nan, Hanzo, Lajos   +3 more
core   +1 more source