Results 81 to 90 of about 2,082,796 (308)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Optimal Actuator Location of the Minimum Norm Controls for Stochastic Heat Equations

open access: yes, 2017
In this paper, we study the approximate controllability for the stochastic heat equation over measurable sets, and the optimal actuator location of the minimum norm controls.
Yang, Donghui, Zhong, Jie
core  

An optimal internet location strategy for markets with different tax rates [PDF]

open access: yes, 2001
The traditional view that a high sales tax rate reduces trade by driving a wedge between the purchase and sale price may not apply to internet commerce for two reasons.
Levin, Eric J., Wright, Robert E.
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Enhancing Radial Distribution System Performance Through Optimal Allocation and Sizing of Photovoltaic and Wind Turbine Distribution Generation Units with Rüppell’s Fox Optimizer

open access: yesMathematics
Renewable energy sources are being progressively incorporated into modern power grids to increase sustainability, stability, and resilience. To ensure that residential, commercial, and industrial customers have a dependable and efficient power supply ...
Yacine Bouali, Basem Alamri
doaj   +1 more source

A Topology Reorganization Scheme for Reliable Communication in Underwater Wireless Sensor Networks Affected by Shadow Zones

open access: yesSensors, 2009
Effective solutions should be devised to handle the effects of shadow zones in Underwater Wireless Sensor Networks (UWSNs). An adaptive topology reorganization scheme that maintains connectivity in multi-hop UWSNs affected by shadow zones has been ...
Mari Carmen Domingo
doaj   +1 more source

Optimal valve location in long oil pipelines [PDF]

open access: yes
We address the valve location problem, one of the basic problems in design of long oil pipelines. Whenever a pipeline is depressurized, the shutoff valves block the oil flow and seal the damaged part of the pipeline.
Grigoriev, A., Grigorieva, N.V.
core   +1 more source

Finding Multiple New Optimal Locations in a Road Network

open access: yes, 2016
We study the problem of optimal location querying for location based services in road networks, which aims to find locations for new servers or facilities. The existing optimal solutions on this problem consider only the cases with one new server.
Cabello S.   +5 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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