Results 81 to 90 of about 1,242,692 (302)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Choosing an optimal connecting place of a nuclear power plant to a power system using Monte Carlo and LHS methods

open access: yesNuclear Engineering and Technology, 2020
The location selection for nuclear power plants (NPP) is a strategic decision, which has significant impact operation of the plant and sustainable development of the region.
Farshid Kiomarsi   +2 more
doaj   +1 more source

Experimental Design of a Prescribed Burn Instrumentation

open access: yes, 2018
Observational data collected during experiments, such as the planned Fire and Smoke Model Evaluation Experiment (FASMEE), are critical for progressing and transitioning coupled fire-atmosphere models like WRF-SFIRE and WRF-SFIRE-CHEM into operational use.
Fournier, Aimé   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Harnessing wind for hydrogen: comparative MCDM-GIS assessment of optimal plant locations

open access: yesJournal of King Saud University: Engineering Sciences
This research aimed to perform an in-depth comparative analysis of MCDM methods, utilizing ArcGIS Pro 3.0.2, to identify the most suitable sites for wind-powered hydrogen production plants in Erbil Governorate, Iraq.
Zakariya Nafi Shehab   +1 more
doaj   +1 more source

Estimating Optimal Landfill Sizes and Locations in North Dakota [PDF]

open access: yes
Resource /Energy Economics and Policy, Land Economics/Use,
Bangsund, Dean A.   +3 more
core   +1 more source

Accurate Feature Extraction and Control Point Correction for Camera Calibration with a Mono-Plane Target [PDF]

open access: yes, 2010
The paper addresses two problems related to 3D camera calibration using a single mono-plane calibration target with circular control marks. The first problem is how to compute accurately the locations of the features (ellipses) in images of the target ...
Fisher, Bob, Xiao, Y.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Optimal Sensor Locations for Structural Identification [PDF]

open access: yes
The optimum sensor location problem, OSLP, may be thought of in terms of the set of systems, S, the class of input time functions, I, and the identification algorithm (estimator) used, E.
Garba, J., Udwadia, F. E.
core   +1 more source

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