Results 81 to 90 of about 1,250,546 (301)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Improving Kinematic Accuracy of Soft Wearable Data Gloves by Optimizing Sensor Locations

open access: yesSensors, 2016
Bending sensors enable compact, wearable designs when used for measuring hand configurations in data gloves. While existing data gloves can accurately measure angular displacement of the finger and distal thumb joints, accurate measurement of thumb ...
Dong Hyun Kim   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Harnessing wind for hydrogen: comparative MCDM-GIS assessment of optimal plant locations

open access: yesJournal of King Saud University: Engineering Sciences
This research aimed to perform an in-depth comparative analysis of MCDM methods, utilizing ArcGIS Pro 3.0.2, to identify the most suitable sites for wind-powered hydrogen production plants in Erbil Governorate, Iraq.
Zakariya Nafi Shehab   +1 more
doaj   +1 more source

Optimal exact designs of experiments via Mixed Integer Nonlinear Programming [PDF]

open access: yes, 2019
Optimal exact designs are problematic to find and study because there is no unified theory for determining them and studyingtheir properties.
Duarte, Belmiro P.M.   +2 more
core  

Experimental Design of a Prescribed Burn Instrumentation

open access: yes, 2018
Observational data collected during experiments, such as the planned Fire and Smoke Model Evaluation Experiment (FASMEE), are critical for progressing and transitioning coupled fire-atmosphere models like WRF-SFIRE and WRF-SFIRE-CHEM into operational use.
Fournier, Aimé   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Choosing an optimal connecting place of a nuclear power plant to a power system using Monte Carlo and LHS methods

open access: yesNuclear Engineering and Technology, 2020
The location selection for nuclear power plants (NPP) is a strategic decision, which has significant impact operation of the plant and sustainable development of the region.
Farshid Kiomarsi   +2 more
doaj   +1 more source

Optimizing the Access to Healthcare Services in Dense Refugee Hosting Urban Areas: A Case for Istanbul

open access: yes, 2019
With over 3.5 million refugees, Turkey continues to host the world's largest refugee population. This introduced several challenges in many areas including access to healthcare system.
Basak Bilecen   +7 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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