Results 91 to 100 of about 5,095,233 (306)

Determination optimal coating mode [PDF]

open access: yes, 2012
There are several ways of coating mode determination during tablets preparation. Experiment planning is one of them. We had three factors (tablets temperature, pan speed and coating films rate) and found their rational proportion.
Ulomsky, E. N.   +7 more
core  

On Sliding Mode Observers for Systems with Unknown Inputs [PDF]

open access: yes, 2007
International audienceThis paper considers the problem of designing an observer for a linear system subject to unknown inputs. This problem has been extensively studied in the literature with respect to both linear and nonlinear (sliding mode) observers.
Floquet, Thierry   +8 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Optimal Sliding Line Selection for Second-Order Nonlinear Systems

open access: yesIEEE Access
This paper focuses on the fundamental problem of sliding line selection in sliding mode control of second-order nonlinear dynamical systems. Although real dynamical systems are rarely accurately described by second-order differential equations, they are ...
Katarzyna Adamiak, Andrzej Bartoszewicz
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

External cavity mode structure of a two-mode VCSEL subject to optical feedback [PDF]

open access: yes, 2007
We consider a multi-transverse-mode vertical-cavity surface-emitting laser (VCSEL) subject to optical feedback. The system is modeled by a partial differential equation for the spatial carrier population, which is coupled to delay differential equations ...
Green, K   +5 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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