Results 91 to 100 of about 774,682 (254)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Advanced Scientometric Analysis of Scientific Machine Learning and PINNs: Topic Modeling and Trend Analysis

IEEE Access
Scientific machine learning and physics-informed neural networks are novel conceptual approaches that integrate scientific knowledge with methods from data science and deep learning.
Frank Emmert-Streib, Shailesh Tripathi, Amer Farea, Olli Yli-Harja   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Topic Modeling of Skincare Comments from Female Daily

Journal of Applied Informatics and Computing
The increasing popularity of skincare products in Indonesia has encouraged many consumers to seek and share information through online platforms. One of the most influential platforms is Female Daily, which provides a space for users to review and ...
Nabila Nabila, Chanifah Indah Ratnasari
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Yield of Brain MRI in Clinically Diagnosed Epilepsy in the Kingdom of Bhutan: A Prospective Study

Annals of Global Health, 2017
Background: People with epilepsy (PWE) in low- and middle-income countries may not access the health resources that are considered optimal for epilepsy diagnosis. The diagnostic yield of magnetic resonance imaging (MRI) has not been well studied in these
Veronica Bruno, Joshua P. Klein, Dechen Nidup, Damber K. Nirola, Lhab Tshering, Sonam Deki, Sarah J. Clark, Kristin A. Linn, Russell T. Shinohara, Chencho Dorji, Dili Ram Pokhrel, Ugyen Dema, Farrah J. Mateen, for the Bhutan Epilepsy Project   +13 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Design optimization of a circular enclosure with flexible fins: Fluid-Structure interaction and heat transfer analysis using rotating frame modeling

Case Studies in Thermal Engineering
This study optimizes heat transfer in a circular vessel containing cold and hot cylinders, a rotating frame, and flexible baffles designed to enhance thermal exchange. Optimized design of such topics improves the performance of heat exchangers.
Ali Qassim Abd Al-Hassan, Muneer A. Ismael, Mohammad Ghalambaz, Ali Chamkha, Mohamed Bechir Ben Hamida   +4 more
doaj   +1 more source

The Optimal Number of Topics Detection and their Assessment in Multiple Current Events and Trends Based Datasets Using Topic Models

International Journal for Research in Applied Science and Engineering Technology
This project explores the application of sophisticated topic models to determine the ideal amount of subjects and evaluate them across several datasets pertaining to trends and current events. We propose a comprehensive approach that leverages the topic models such as Latent Dirichlet Allocation (LDA), Non-negative Matrix Factorization (NMF), Latent ...
openaire   +1 more source