Results 71 to 80 of about 774,682 (254)

Evaluating association between linguistic characteristics of abstracts and risk of bias: Case of Japanese randomized controlled trials. [PDF]

PLoS ONE, 2017
Despite the ongoing growth in the number of published randomized controlled trials (RCTs) and increased quality assessment of RCTs, the association between the quality and characteristics in the text has not been sufficiently studied.
Daisuke Yoneoka, Erika Ota
doaj   +1 more source

A data-driven analysis to determine the optimal number of topics 'K' for latent Dirichlet allocation model

Indonesian Journal of Electrical Engineering and Computer Science
Topic modeling is an unsupervised machine learning technique successfully used to classify and retrieve textual data. However, the performance of topic models is sensitive to selecting optimal hyperparameters, the number of topics 'K' and Dirichlet priors 'α' and 'β.' This data-driven analysis aims to determine the optimum number of topics, 'K,' within
Astha Goyal, Indu Kashyap
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Japanese Expert Panel Meeting on the Management of Prostate Cancer with Bone Metastases

Oncology and Therapy, 2018
Introduction The incidence of prostate cancer in Japan continues to increase, necessitating the continued development of effective therapies and strategies.
Shunji Takahashi, Seigo Kinuya, Norio Nonomura, Nobuo Shinohara, Kazuhiro Suzuki, Hiroyoshi Suzuki, Katsumasa Nakamura, Takefumi Satoh, Ukihide Tateishi, Toshiyuki Yoneda, Hiroyuki Horikoshi, Tsukasa Igawa, Takao Kamai, Mitsuru Koizumi, Takeo Kosaka, Nobuaki Matsubara, Hideaki Miyake, Atsushi Mizokami, Takashi Mizowaki, Naoki Nakamura, Masahiro Nozawa, Takeo Takahashi, Hiroji Uemura, Motohide Uemura, Akira Yokomizo, Mana Yoshimura, Yoshiyuki Kakehi   +26 more
doaj   +1 more source

Antitrust Perspectives for Durable-Goods Markets [PDF]

Markets for durable goods constitute an important part of the economy. In this paper I first briefly review the microeconomic theory literature on durable-goods markets, focusing mostly on the last ten years.
Michael Waldman
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mapping interconnectivity of digital twin healthcare research themes through structural topic modeling

Scientific Reports
Digital twin (DT) technology is revolutionizing healthcare systems by leveraging real-time data integration and advanced analytics to enhance patient care, optimize clinical operations, and facilitate simulation. This study aimed to identify key research
Eun Man Kim, Yooseok Lim
doaj   +1 more source

Influence of Geometric Equations in Mixed Problem of Porous Micromorphic Bodies with Microtemperature

Mathematics, 2020
The study of the mixed initial-boundary value problem, corresponding to the thermoelasticity of porous micromorphic materials under the influence of microtemperatures, represents the main objective of this article.
Lavinia Codarcea-Munteanu, Marin Marin
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source