Results 61 to 70 of about 774,682 (254)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Altitude Training: Strong Bounds for Single-Layer Dropout [PDF]
, 2014 Dropout training, originally designed for deep neural networks, has been successful on high-dimensional single-layer natural language tasks. This paper proposes a theoretical explanation for this phenomenon: we show that, under a generative Poisson topic
Fithian, William +3 more
core +1 more source
Leveraging Crowdsourcing Data For Deep Active Learning - An Application: Learning Intents in Alexa
, 2018 This paper presents a generic Bayesian framework that enables any deep learning model to actively learn from targeted crowds. Our framework inherits from recent advances in Bayesian deep learning, and extends existing work by considering the targeted ...
Damianou, Andreas +3 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Journal of Big DataTopic modeling methods proved to be effective for inferring latent topics from short texts. Dealing with short texts is challenging yet helpful for many real-world applications, due to the sparse terms in the text and the high dimensionality ...
Mutasem K. Alsmadi +8 more
doaj +1 more source
New topic detection in microblogs and topic model evaluation using topical alignment [PDF]
, 2014 textThis thesis deals with topic model evaluation and new topic detection in microblogs. Microblogs are short and thus may not carry any contextual clues.
Rajani, Nazneen Fatema
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Моделирование и анализ информационных систем, 2014 The workshop of the Nonlinear Dynamics scientific-educational center continued its work in 2014, focusing on methods of the dynamical system analysis and studies of their behavior. More than 30 talks in the field of scientific-educational center research
Статья Редакционная
doaj +1 more source