Results 41 to 50 of about 2,772,611 (235)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Jurnal SisfokomBiomedical research has become an essential entity in human life. However, finding trends related to research topics in the health sector contained in the repository is a challenging matter.
Yuri Pamungkas
doaj +1 more source
Optimal Path Choice in Railway Passenger Travel Network Based on Residual Train Capacity
The Scientific World Journal, 2014 Passenger’s optimal path choice is one of the prominent research topics in the field of railway passenger transport organization. More and more different train types are available, increasing path choices from departure to destination for travelers are ...
Fei Dou +4 more
doaj +1 more source
AOBTM: Adaptive Online Biterm Topic Modeling for Version Sensitive Short-texts Analysis [PDF]
arXiv, 2020 Analysis of mobile app reviews has shown its important role in requirement engineering, software maintenance and evolution of mobile apps. Mobile app developers check their users' reviews frequently to clarify the issues experienced by users or capture the new issues that are introduced due to a recent app update.
arxiv
ProSiT! Latent Variable Discovery with PROgressive SImilarity Thresholds [PDF]
arXiv, 2022 The most common ways to explore latent document dimensions are topic models and clustering methods. However, topic models have several drawbacks: e.g., they require us to choose the number of latent dimensions a priori, and the results are stochastic.
arxiv
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Sequential Topic Selection Model with Latent Variable for Topic-Grounded Dialogue [PDF]
arXiv, 2022 Recently, topic-grounded dialogue system has attracted significant attention due to its effectiveness in predicting the next topic to yield better responses via the historical context and given topic sequence. However, almost all existing topic prediction solutions focus on only the current conversation and corresponding topic sequence to predict the ...
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies
Molecular Oncology, EarlyView.Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren +16 more
wiley +1 more source