Results 51 to 60 of about 93,510 (232)

Hybrid topic modeling method based on dirichlet multinomial mixture and fuzzy match algorithm for short text clustering

Journal of Big Data
Topic modeling methods proved to be effective for inferring latent topics from short texts. Dealing with short texts is challenging yet helpful for many real-world applications, due to the sparse terms in the text and the high dimensionality ...
Mutasem K. Alsmadi, Malek Alzaqebah, Sana Jawarneh, Ibrahim ALmarashdeh, Mohammed Azmi Al-Betar, Maram Alwohaibi, Noha A. Al-Mulla, Eman AE Ahmed, Ahmad AL Smadi   +8 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Seminar “Nonlinear Dynamics”

Моделирование и анализ информационных систем, 2014
The workshop of the Nonlinear Dynamics scientific-educational center continued its work in 2014, focusing on methods of the dynamical system analysis and studies of their behavior. More than 30 talks in the field of scientific-educational center research
Статья Редакционная
doaj   +1 more source

Evaluating association between linguistic characteristics of abstracts and risk of bias: Case of Japanese randomized controlled trials. [PDF]

PLoS ONE, 2017
Despite the ongoing growth in the number of published randomized controlled trials (RCTs) and increased quality assessment of RCTs, the association between the quality and characteristics in the text has not been sufficiently studied.
Daisuke Yoneoka, Erika Ota
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Japanese Expert Panel Meeting on the Management of Prostate Cancer with Bone Metastases

Oncology and Therapy, 2018
Introduction The incidence of prostate cancer in Japan continues to increase, necessitating the continued development of effective therapies and strategies.
Shunji Takahashi, Seigo Kinuya, Norio Nonomura, Nobuo Shinohara, Kazuhiro Suzuki, Hiroyoshi Suzuki, Katsumasa Nakamura, Takefumi Satoh, Ukihide Tateishi, Toshiyuki Yoneda, Hiroyuki Horikoshi, Tsukasa Igawa, Takao Kamai, Mitsuru Koizumi, Takeo Kosaka, Nobuaki Matsubara, Hideaki Miyake, Atsushi Mizokami, Takashi Mizowaki, Naoki Nakamura, Masahiro Nozawa, Takeo Takahashi, Hiroji Uemura, Motohide Uemura, Akira Yokomizo, Mana Yoshimura, Yoshiyuki Kakehi   +26 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Mapping interconnectivity of digital twin healthcare research themes through structural topic modeling

Scientific Reports
Digital twin (DT) technology is revolutionizing healthcare systems by leveraging real-time data integration and advanced analytics to enhance patient care, optimize clinical operations, and facilitate simulation. This study aimed to identify key research
Eun Man Kim, Yooseok Lim
doaj   +1 more source

Influence of Geometric Equations in Mixed Problem of Porous Micromorphic Bodies with Microtemperature

Mathematics, 2020
The study of the mixed initial-boundary value problem, corresponding to the thermoelasticity of porous micromorphic materials under the influence of microtemperatures, represents the main objective of this article.
Lavinia Codarcea-Munteanu, Marin Marin
doaj   +1 more source