Results 41 to 50 of about 7,766,584 (280)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A power grid partitioning method based on complex network coupling matrices

Zhejiang dianli
To scientifically and effectively determine the layout of stability control systems， accurately identify partition interfaces， and enhance the operational security of large-scale power grids， this paper proposes a power grid partitioning method based on ...
XIONG Jun, TANG Fan, CHEN Zeming, WANG Yimiao, MEI Tao   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Adaptive Partitioning for Large-Scale Dynamic Graphs [PDF]

, 2013
—In the last years, large-scale graph processing has gained increasing attention, with most recent systems placing particular emphasis on latency. One possible technique to improve runtime performance in a distributed graph processing system is to reduce
Martella, Claudio, Martella, C, Dionysios Logothetis, Cuadrado, Félix, Logothetis, Dionysios, Felix Cuadrado, Cuadrado, F, Vaquero, Luis M., Logothetis, D, Luis Vaquero, Luis M. Vaquero, Claudio Martella, Vaquero, LM, IEEE   +13 more
core   +1 more source

Biomass allocation between reproductive and vegetative organs of Artemisia along a large environmental gradient

BMC Plant Biology
Background Biomass allocation reflects functional tradeoffs among plant organs and thus represents life history strategies. However, little is known about the patterns and drivers of biomass allocation between reproductive and vegetative organs along ...
Tumenjargal Tsogtsaikhan, Xuejun Yang, Ruiru Gao, Jiangrui Liu, Wenqiang Tang, Guofang Liu, Xuehua Ye, Zhenying Huang   +7 more
doaj   +1 more source

Above- and Belowground Biomass Allocation in Shrub Biomes across the Northeast Tibetan Plateau.

PLoS ONE, 2016
Biomass partitioning has been explored across various biomes. However, the strategies of allocation in plants still remain contentious. This study investigated allocation patterns of above- and belowground biomass at the community level, using biomass ...
Xiuqing Nie, Yuanhe Yang, Lucun Yang, Guoying Zhou   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Exploring the Relative Importance and Interactive Impacts of Explanatory Variables of the Built Environment on Ride-Hailing Ridership by Using the Optimal Parameter-Based Geographical Detector (OPGD) Model

Applied Sciences, 2023
The impact of the built environment on the ridership of ride-hailing results depends on the spatial grid scale. The existing research on the demand model of ride-hailing ignores the modifiable areal unit problem (MAUP).
Zhenbao Wang, Shuyue Liu, Yuchen Zhang, Xin Gong, Shihao Li, Dong Liu, Ning Chen   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Employment trajectories of workers in low-skilled jobs in Western Germany

Journal for Labour Market Research, 2023
According to the segmentation theory, low-skilled jobs belong to the secondary sector of the labour market. Low-skilled jobs do not require vocational training and workers are interchangeable.
Arthur Kaboth, Lena Hünefeld, Ralf Himmelreicher   +2 more
doaj   +1 more source