Results 41 to 50 of about 8,067,351 (289)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

A power grid partitioning method based on complex network coupling matrices

Zhejiang dianli
To scientifically and effectively determine the layout of stability control systems， accurately identify partition interfaces， and enhance the operational security of large-scale power grids， this paper proposes a power grid partitioning method based on ...
XIONG Jun, TANG Fan, CHEN Zeming, WANG Yimiao, MEI Tao   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Biomass allocation between reproductive and vegetative organs of Artemisia along a large environmental gradient

BMC Plant Biology
Background Biomass allocation reflects functional tradeoffs among plant organs and thus represents life history strategies. However, little is known about the patterns and drivers of biomass allocation between reproductive and vegetative organs along ...
Tumenjargal Tsogtsaikhan, Xuejun Yang, Ruiru Gao, Jiangrui Liu, Wenqiang Tang, Guofang Liu, Xuehua Ye, Zhenying Huang   +7 more
doaj   +1 more source

Above- and Belowground Biomass Allocation in Shrub Biomes across the Northeast Tibetan Plateau.

PLoS ONE, 2016
Biomass partitioning has been explored across various biomes. However, the strategies of allocation in plants still remain contentious. This study investigated allocation patterns of above- and belowground biomass at the community level, using biomass ...
Xiuqing Nie, Yuanhe Yang, Lucun Yang, Guoying Zhou   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Exploring the Relative Importance and Interactive Impacts of Explanatory Variables of the Built Environment on Ride-Hailing Ridership by Using the Optimal Parameter-Based Geographical Detector (OPGD) Model

Applied Sciences, 2023
The impact of the built environment on the ridership of ride-hailing results depends on the spatial grid scale. The existing research on the demand model of ride-hailing ignores the modifiable areal unit problem (MAUP).
Zhenbao Wang, Shuyue Liu, Yuchen Zhang, Xin Gong, Shihao Li, Dong Liu, Ning Chen   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Employment trajectories of workers in low-skilled jobs in Western Germany

Journal for Labour Market Research, 2023
According to the segmentation theory, low-skilled jobs belong to the secondary sector of the labour market. Low-skilled jobs do not require vocational training and workers are interchangeable.
Arthur Kaboth, Lena Hünefeld, Ralf Himmelreicher   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source