Results 51 to 60 of about 7,766,584 (280)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Converging many-body perturbation theory for ab-initio nuclear structure: Brillouin-Wigner perturbation series for closed-shell nuclei

Physics Letters B
Convergence aspects of nuclear many-body perturbation theory for ground states of closed-shell nuclei are explored using a Brillouin-Wigner formulation with a new vertex function enabling high-order calculations.
Zhen Li, Nadezda A. Smirnova
doaj   +1 more source

Morphological correlates of prey consumed by Podarcis melisellensis (Braun, 1877) and P. siculus (Rafinesque, 1810) (Sauria, Lacertidae) from two mainland regions in the eastern Adriatic area [PDF]

Archives of Biological Sciences, 2013
The correlation between trophic utilization and morphology was studied for two lizard species (Podarcis melisellensis and P. siculus) from two mainland localities in the eastern Adriatic area; this is the first report of trophic and morphometric data ...
Stamenković S.Ž., Matić Rada
doaj   +1 more source

Intelligent Optimization Method for Core Flow Zoning of Long-Cycle Lead-Bismuth-Cooled Reactor

Frontiers in Energy Research, 2022
Flow zoning is an important way to achieve core outlet temperature flattening. Appropriate zoning can improve safety and economy. This study combines an artificial intelligence optimization algorithm with a parallel multi-channel model to develop a model
Qingyuan Yu, Shengqi Dai, Pengcheng Zhao, Pengcheng Zhao, Yanan Zhao, Yingjie Xiao, Liangxing Peng, Tao Yu   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Migration and commuting interactions fields: a new geography with community detection algorithm?

Belgeo, 2017
The objective is to refresh the geography of Belgium using interactions between places by means of a community detection algorithm (Louvain Method) inspired by Complex theory and Data Sciences. Places that are tightly related are optimally clustered into
Isabelle Thomas, Arnaud Adam, Ann Verhetsel   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Good Fences Make Good Neighbors: Adjacent Honey Bee Colonies Locally Partition Their Foraging Across Landscapes

Ecology and Evolution
Optimal foraging theory (OFT) predicts that animals employ foraging strategies that maximize a particular currency, such as net energetic efficiency, to meet their nutritional demands. Two nonexclusive patterns that arise from OFT are convergence on high‐
Bradley D. Ohlinger, Margaret J. Couvillon, Laurence W. Carstensen, Roger Schürch   +3 more
doaj   +1 more source

Biogeochemical and Ecomorphological Niche Segregation of Mediterranean Woody Species along a Local Gradient

Frontiers in Plant Science, 2017
According with niche theory the species are specialized in different ecological niches, being able to coexist as result of a differential use of resources.
Enrique G. de la Riva, Enrique G. de la Riva, Teodoro Marañón, Cyrille Violle, Rafael Villar, Ignacio M. Pérez-Ramos   +5 more
doaj   +1 more source