Results 101 to 110 of about 5,635,969 (342)
Optimal Placement of Low-Altitude Aerial Base Station for Securing Communications
IEEE Wireless Communications Letters, 2019 Because of its cost-effective and on-demand deployment, low-altitude aerial base stations (BSs) are capable of providing emergency communication services in many scenarios. This letter investigates the security issue in emergency communications where the
Dong Wang +3 more
semanticscholar +1 more source
Optimal Sensors Placement to Enhance Damage Detection in Composite Plates [PDF]
, 2014 This paper examines an important challenge in ultrasonic structural health monitoring (SHM), which is the problem of the optimal placement of sensors in order to accurately detect and localize damages.
COFFIGNAL, Gérard +5 more
core +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2012 The amount of hydrocarbon recovered can be considerably increased by finding optimal placement of non-conventional wells. For that purpose, the use of optimization algorithms, where the objective function is evaluated using a reservoir simulator, is needed. Furthermore, for complex reservoir geologies with high heterogeneities, the optimization problem
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Standard Cell Placement Optimization Using Quadratic Placement Algorithm
OALib, 2020 Designs including tens of millions of standard cells in one chip are commonly used in current IC projects, so finding optimal location on a chip surface for each logic cell is a very important step in IC design. Apart from finding room for logic cell placement with minimum chip area, length of connecting wires is also playing big role and needs to be ...
Suren Abazyan +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
IEEE AccessA novel modified whale optimization algorithm (MWOA) is presented in this study to minimize transmission losses. The proposed method is used to determine the best control variables, such as reactive power generation, transformer tap settings, and ...
Manoj Kumar Kar +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source