Results 81 to 90 of about 3,761,593 (295)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Spatio-Temporal Field Estimation Using Kriged Kalman Filter (KKF) with Sparsity-Enforcing Sensor Placement

Sensors, 2018
We propose a sensor placement method for spatio-temporal field estimation based on a kriged Kalman filter (KKF) using a network of static or mobile sensors. The developed framework dynamically designs the optimal constellation to place the sensors.
Venkat Roy, Andrea Simonetto, Geert Leus
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Optimal Sensor Placement in a Partitioned Water Distribution Network for the Water Protection from Contamination

Proceedings, 2018
Water network protection from accidental and intentional contamination is one of the most critical issues for preserving the citizen health. Recently, some techniques have been proposed in the literature to define the optimal sensor placement.
Carlo Ciaponi, Enrico Creaco, Armando Di Nardo, Michele Di Natale, Carlo Giudicianni, Dino Musmarra, Giovanni Francesco Santonastaso   +6 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

A deployment value model for intrusion detection sensors [PDF]

, 2009
The value of an intrusion detection sensor is often associated with its data collection and analysis features. Experience tells us such sensors fall under a range of different types and are diverse in their operational characteristics. There is a need
Hao Chen, John A. Clark, Nobles, P., Clark, J.A., Clark, John A., Nobles, Philip, Howard Chivers, Philip Nobles, Chivers, Howard, Siraj A. Shaikh, Chen, H., Shaikh, Siraj A., Chen, Hao, Chivers, H.   +13 more
core   +1 more source

OSP-SAP: A MATLAB graphical user interface for optimal sensor placement using SAP2000

SoftwareX
An optimal placement of sensors is key for structural modal identification since it critically determines the quality of the estimated modal properties.
Antonio S. López-Cuervo, Enrique García-Macías, Rafael Castro-Triguero, Juan Chiachío   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Sensor Placement Optimization of Vibration Test on Medium-Speed Mill

Shock and Vibration, 2015
Condition assessment and decision making are important tasks of vibration test on dynamic machines, and the accuracy of dynamic response can be achieved by the sensors placed on the structure reasonably.
Lihua Zhu, Jun Dai, Guoliang Bai
doaj   +1 more source