Results 91 to 100 of about 4,146,021 (290)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Optimal plot size for experimental trials with Opuntia cactus pear
Acta Scientiarum: Technology, 2019 The objective of the study with `Gigante´ cactus pear was to determine the size of plots that optimize the implementation of experiments with greater accuracy, spatial adequacy and efficiency of use of the experimental area by the Hatheway method (1961).
Bruno Vinícius Castro Guimarães +4 more
doaj +1 more source
, 1987 A method for structural member sizing optimization to be used for designing planar frames is presented. The procedure is based on the Augmented Lagrangian Multiplier method. The algorithm includes the displacements as state variables and consequently combines the analysis and the search for the optimal section properties into a single step.
Alfredo Soeiro, Hoit, M
openaire +1 more source
Is there an optimal board size?
Corporate Board role duties and composition, 2009 This research quantitatively examines the determinants of board size and the consequence it has on the performance of large companies in Australia. In line with international and the prevalent United States research the results suggest that there is no significant relationship between board size and their subsequent performance.
Yi Wang, Antony Young, Sally Chaplin
openaire +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Life span and the problem of optimal population size [PDF]
We reconsider the optimal population size problem in a continuous time economy populated by homogenous cohorts with a fixed life span. This assumption is combined with a linear production function in the labor input and standard rearing costs.
Fausto Gozzi +2 more
core +3 more sources
Two-Stage Adaptive Optimal Design with Fixed First-Stage Sample Size
Journal of Probability and Statistics, 2012 In adaptive optimal procedures, the design at each stage is an estimate of the optimal design based on all previous data. Asymptotics for regular models with fixed number of stages are straightforward if one assumes the sample size of each stage goes to ...
Adam Lane, Nancy Flournoy
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source