Results 111 to 120 of about 4,146,021 (290)

The Optimal Size of German Cities An Efficiency Analysis Perspective [PDF]

open access: yes
This work investigates the interrelation between production efficiency and population size of German cities. The productive efficiency in this context is the scale efficiency, which is a result of positive and negative agglomeration externalities.
Hitzschke, Stephan
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Optimal Fleet Size When National Quotas Can Be Traded [PDF]

open access: yes
Assuming stochastic quotas for a fish stock that is shared between two nations, we find the optimal fleet size for one of them by maximizing expected profit under the assumption that national quotas can be traded and that stable national quotas is a ...
Brekke, Karl, Wallace, Stein W.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

drugdevelopR: Planning of phase II/III drug development programs with optimal sample size allocation and Go/No-go decision rules in R

open access: yesSoftwareX
Sample size determination is crucial in phase II/III drug development programs, impacting the likelihood of meeting program objectives. Within a utility-based framework, methods for optimal designs were developed recently, i.e., optimal go/no-go decision
Johannes Cepicka   +4 more
doaj   +1 more source

Coordination Behavior and Optimal Committee Size [PDF]

open access: yes
How many members should committees consist of? This paper addresses this question in view of imperfect information and coordination behavior among the members, which is a new approach alternative to introducing information acquisition cost.
Keiichi Morimoto
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Optimal Plot Size in Experimentation with Clonal Cacao Seedlings

open access: yesAgriculture
The cacao tree (Theobroma cacao L.) is a crop of great economic importance to Brazil and has undergone several breeding processes that, among other things, have made it possible to obtain several self-compatible genotypes, ensuring that there is no ...
Letícia Galvão Morais   +9 more
doaj   +1 more source

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