Results 101 to 110 of about 4,146,021 (290)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Modeling optimal drone fleet size considering stochastic demand
EURO Journal on Transportation and LogisticsThe last mile delivery is particularly challenging for stochastic deliveries with narrow time windows. This topic is timely due to the rise of e-commerce and courier type services and the impacts of fleet size and vehicle type on delivery costs.
Yuval Hadas, Miguel A. Figliozzi
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies
Frontiers in Neuroscience, 2019 Advances in microfabrication technology have enabled the production of devices containing arrays of thousands of closely spaced recording electrodes, which afford subcellular resolution of electrical signals in neurons and neuronal networks ...
Vijay Viswam +7 more
doaj +1 more source
On the Optimal Size and Composition of Customs Unions: An Evolutionary Approach. [PDF]
Comput Econ, 2023 Saber T, Naeher D, De Lombaerde P.
europepmc +1 more source
P.Size: a sizing aid for optimized designs
Proceedings EURO-DAC '92: European Design Automation Conference, 2003 Transistor sizing at layout level is necessary to improve the overall performance of integrated circuits. The authors present the definition and the validation of a sizing aid, P.Size, integrated in a flexible cell generator. Based on a local optimization defined through an explicit formulation of delays, this sizing aid can be used to optimize real ...
Azemard, Nadine +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Extracting Several Resource Deposits of Unknown Size: Optimal Order [PDF]
Oil companies often announce revised estimates of their reserves. This indicates that stock uncertainty is a prevalent feature of natural resource industries. In this paper we consider the multi-deposit case where resource extraction produces information
Murray C. Kemp, Ngo Van Long
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source