Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Modeling optimal drone fleet size considering stochastic demand
EURO Journal on Transportation and LogisticsThe last mile delivery is particularly challenging for stochastic deliveries with narrow time windows. This topic is timely due to the rise of e-commerce and courier type services and the impacts of fleet size and vehicle type on delivery costs.
Yuval Hadas, Miguel A. Figliozzi
doaj +1 more source
Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies
Frontiers in Neuroscience, 2019 Advances in microfabrication technology have enabled the production of devices containing arrays of thousands of closely spaced recording electrodes, which afford subcellular resolution of electrical signals in neurons and neuronal networks ...
Vijay Viswam +7 more
doaj +1 more source
Extracting Several Resource Deposits of Unknown Size: Optimal Order [PDF]
Oil companies often announce revised estimates of their reserves. This indicates that stock uncertainty is a prevalent feature of natural resource industries. In this paper we consider the multi-deposit case where resource extraction produces information
Murray C. Kemp, Ngo Van Long
core
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
The optimal size of screw for using cement-screw technique to repair tibial defect in total knee arthroplasty: A finite element analysis. [PDF]
Heliyon, 2023 Ma J, Xu C, Zhao G, Xiao L, Wang J.
europepmc +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
The Optimal Size of German Cities An Efficiency Analysis Perspective [PDF]
This work investigates the interrelation between production efficiency and population size of German cities. The productive efficiency in this context is the scale efficiency, which is a result of positive and negative agglomeration externalities.
Hitzschke, Stephan
core
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Enhancing User Experience of Eye-Controlled Systems: Design Recommendations on the Optimal Size, Distance and Shape of Interactive Components from the Perspective of Peripheral Vision. [PDF]
Int J Environ Res Public Health, 2022 Niu Y +7 more
europepmc +1 more source