Results 101 to 110 of about 487,210 (299)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Towards the justification of optimal volumes of repair production of locomotives of diesel tractions [PDF]

E3S Web of Conferences
A methodology and algorithm for determining the optimal volume of repairs with known cyclicity of repair production and between-repair runs of mainline diesel locomotives of the TE10 series and the UzTE16M series in various sectional designs is presented.
Ablyalimov Oleg, Adilova Nazdana
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Re-Modeling of a Polymeric Drug Delivery System Using Smart Response Surface Designs: A Sustainable Approach for the Consumption of Fewer Resources

ChemEngineering
Introduction: The use of response surface designs for drug formulation is highly warranted nowadays. Such smart designs reduce the number of required experiments compared to full-factorial designs, while providing highly accurate and reliable results ...
Magdy M. Aly, Shaimaa S. Ibrahim, Rania M. Hathout   +2 more
doaj   +1 more source

Design of economically and statistically optimal sampling plans

Hacettepe Journal of Mathematics and Statistics, 2016
This paper attempts to develop four types of acceptance sampling plans under the objectives of minimizing the total loss to the producer and consumer and maximizing the rate of approaching to the ideal operat ing characteristic (OC) curve when the quality characteristic follows a normal distribution and has lower specication limit.
NEZHAD, Mohammad Saber Fallah, SAREDORAHİ, Faeze Zahmatkesh, OWLİA, Mohammad Saleh, ZAD, Mohammad Ali Vahdat   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Experimental Design for Sensitivity Analysis, Optimization and Validation of Simulation Models [PDF]

This chapter gives a survey on the use of statistical designs for what-if analysis in simula- tion, including sensitivity analysis, optimization, and validation/verification. Sensitivity analysis is divided into two phases.
Kleijnen, J.P.C.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evaluation of performance and statistical analysis of rigid pavement incorporating recycled aggregate concrete through the BBD methodology

Materials Research Express
The incorporation of recycled concrete aggregate (RCA) in the construction of rigid pavements has attracted considerable interest due to its environmental and economic benefits.
Karuppasamy S, Ganapathi Malarvizhi
doaj   +1 more source

Optimized Floating Offshore Wind Turbine Substructure Design Trends for 10–30 MW Turbines in Low-, Medium-, and High-Severity Wave Environments

Designs
Floating offshore wind is a promising renewable energy source, as 60% of the wind resources globally are found at depths requiring floating technologies, it minimizes construction at sea, and provides opportunities for industrialization given a lower ...
Joseph Habib Dagher, Andrew J. Goupee, Anthony M. Viselli   +2 more
doaj   +1 more source