Results 91 to 100 of about 121,104 (312)
Bayesian and maximin optimal designs for heteroscedastic regression models [PDF]
The problem of constructing standardized maximin D-optimal designs for weighted polynomial regression models is addressed. In particular it is shown that, by following the broad approach to the construction of maximin designs introduced recently by Dette,
Dette, Holger +2 more
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Optimal designs for full and partial likelihood information - with application to survival models [PDF]
, 2015 Time-to-event data are often modelled through Cox's proportional hazards model for which inference is based on the partial likelihood function. We derive a general expression for the asymptotic covariance matrix of Cox's partial likelihood estimator for ...
Konstantinou, Maria +3 more
core +1 more source
ChemEngineeringIntroduction: The use of response surface designs for drug formulation is highly warranted nowadays. Such smart designs reduce the number of required experiments compared to full-factorial designs, while providing highly accurate and reliable results ...
Magdy M. Aly +2 more
doaj +1 more source
Towards the justification of optimal volumes of repair production of locomotives of diesel tractions [PDF]
E3S Web of ConferencesA methodology and algorithm for determining the optimal volume of repairs with known cyclicity of repair production and between-repair runs of mainline diesel locomotives of the TE10 series and the UzTE16M series in various sectional designs is presented.
Ablyalimov Oleg, Adilova Nazdana
doaj +1 more source
Designing the statistically optimal drug for cancer therapy
, 2013 16 pages, 8 ...
Lawlor, Patrick N. +5 more
openaire +2 more sources
Design of economically and statistically optimal sampling plans
Hacettepe Journal of Mathematics and Statistics, 2016 This paper attempts to develop four types of acceptance sampling plans under the objectives of minimizing the total loss to the producer and consumer and maximizing the rate of approaching to the ideal operat ing characteristic (OC) curve when the quality characteristic follows a normal distribution and has lower specication limit.
NEZHAD, Mohammad Saber Fallah +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Optimal cross-over designs for full interaction models
, 2013 We consider repeated measurement designs when a residual or carry-over effect may be present in at most one later period. Since assuming an additive model may be unrealistic for some applications and leads to biased estimation of treatment effects, we ...
P. Druilhet +4 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source