Results 91 to 100 of about 487,210 (299)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Channel Estimation for Diffusive Molecular Communications

, 2016
In molecular communication (MC) systems, the \textit{expected} number of molecules observed at the receiver over time after the instantaneous release of molecules by the transmitter is referred to as the channel impulse response (CIR).
Ahmadzadeh, Arman, Jamali, Vahid, Jardin, Christophe, Schober, Robert, Sticht, Heinrich   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Reducing noise levels in eddy current measurements using self-differential probes of the substrate conductivity under a layer of conductive coating in moved objects

Scientific Reports
In the research, the method of reducing the levels of all noises caused by uncontrollable interfering factors has been generalized and extended to surface eddy current conductivity meters of the substrate under a layer of non-ferromagnetic metal coating.
Volodymyr Ya. Halchenko, Ruslana Trembovetska, Volodymyr Tychkov   +2 more
doaj   +1 more source

REVISITING BID DESIGN ISSUES IN CONTINGENT VALUATION [PDF]

A uniform bid design from a predetermined uniform distribution is proposed as a practical and robust alternative to existing optimal or naïve bid designs.
Haab, Timothy C., Kim, Sooil
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Bias and Efficiency of Uniform Bid Design in Contingent Valuation [PDF]

While contingent valuation (CV) methods have experienced growing popularity for estimating the willingness to pay for nonmarket goods and services, optimal bid designs for CV that provide guidance in bid point placement often render themselves ...
Kim, Sooil
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Robust designs in non-inferiority three arm clinical trials with presence of heteroscedasticity [PDF]

In this paper, we describe an adjusted method to facilitate a non-inferiority trial by a three-arm robust design. Because local optimal designs derived in Hasler et al.
Dette, Holger, Hothorn, Ludwig A., Trampisch, Matthias   +2 more
core  

Designing the statistically optimal drug for cancer therapy

, 2013
16 pages, 8 ...
Lawlor, Patrick N., Kalisky, Tomer, Quake, Stephen, Rosner, Robert, Rosner, Marsha Rich, Kording, Konrad P.   +5 more
openaire   +2 more sources