Results 11 to 20 of about 482,042 (298)
Approximately optimal subset selection for statistical design and modelling [PDF]
Journal of Statistical Computation and Simulation, 2021 We study the problem of optimal subset selection from a set of correlated random variables. In particular, we consider the associated combinatorial optimization problem of maximizing the determinant of a symmetric positive definite matrix that characterizes the chosen subset. This problem arises in many domains, such as experimental designs, regression
Yu Wang, Nhu D. Le, James V. Zidek
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A Statistical Approach to Optimizing Concrete Mixture Design [PDF]
The Scientific World Journal, 2014 A step-by-step statistical approach is proposed to obtain optimum proportioning of concrete mixtures using the data obtained through a statistically planned experimental program. The utility of the proposed approach for optimizing the design of concrete mixture is illustrated considering a typical case in which trial mixtures were considered according ...
Shamsad Ahmad, Saeid A. Alghamdi
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Chromatin structure and context-dependent sequence features control prime editing efficiency
Frontiers in Genetics, 2023 Prime editing (PE) is a highly versatile CRISPR–Cas9 genome editing technique. The current constructs, however, have variable efficiency and may require laborious experimental optimization.
Somang Kim +15 more
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Influence of local values on cD-optimal designs for logistic models
TecnoLógicas, 2018 When experiments are designed, it is uncommon to use criteria to determine the treatments and number of replicates that should be conducted to properly estimate the parameters in the model under study.
Víctor Ignacio López-Ríos +1 more
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Malaria Journal, 2011 Background Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not ...
Lindegardh Niklas +5 more
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Towards optimal design of anti-malarial pharmacokinetic studies
Malaria Journal, 2009 Background Characterization of anti-malarial drug concentration profiles is necessary to optimize dosing, and thereby optimize cure rates and reduce both toxicity and the emergence of resistance.
White Nicholas J +6 more
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BMC Medical Research Methodology, 2020 Background In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect ...
Xieran Li +2 more
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Global design of analog cells using statistical optimization techniques [PDF]
Analog Integrated Circuits and Signal Processing, 1994 El pdf del artículo es la versión post-print.
Medeiro Hidalgo, Fernando +5 more
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Global optimization of metasurface designs using statistical learning methods [PDF]
Scientific Reports, 2019 AbstractOptimization of the performance of flat optical components, also dubbed metasurfaces, is a crucial step towards their implementation in realistic optical systems. Yet, most of the design techniques, which rely on large parameter search to calculate the optical scattering response of elementary building blocks, do not account for near-field ...
Elsawy, Mahmoud +5 more
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Simulation-based design optimization for statistical power: Utilizing machine learning.
Psychological Methods, 2022 The planning of adequately powered research designs increasingly goes beyond determining a suitable sample size. More challenging scenarios demand simultaneous tuning of multiple design parameter dimensions and can only be addressed using Monte Carlo simulation if no analytical approach is available.
Zimmer, Felix, Debelak, Rudolf
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