Results 31 to 40 of about 118,549 (265)

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar   +7 more
wiley   +1 more source

SSNdesign-An R package for pseudo-Bayesian optimal and adaptive sampling designs on stream networks.

open access: yesPLoS ONE, 2020
Streams and rivers are biodiverse and provide valuable ecosystem services. Maintaining these ecosystems is an important task, so organisations often monitor the status and trends in stream condition and biodiversity using field sampling and, more ...
Alan R Pearse   +6 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo   +5 more
wiley   +1 more source

Cautions on using the Before-After-Control-Impact design in environmental effects monitoring programs

open access: yesFACETS, 2017
Often the Before-After-Control-Impact (BACI) design is suggested as being a statistically powerful experimental design in environmental impact studies.
K.E. Smokorowski, R.G. Randall
doaj   +1 more source

Economic and Economic-Statistical Designs of Multivariate Coefficient of Variation Chart

open access: yesRevstat Statistical Journal, 2022
From the economic perspective, cost minimization is an important part of Statistical Process Control (SPC). The conventional approach in SPC focuses on monitoring the process mean and variance for possible shifts. In some processes, such as clinical and
Wei Chun Ng   +3 more
doaj   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte   +5 more
wiley   +1 more source

Robust Superimposed Training Designs for MIMO Relaying Systems Under General Power Constraints

open access: yesIEEE Access, 2019
In this paper, we investigate the superimposed training matrix designs for the channel estimation of amplify-and-forward (AF) multiple-input multiple-output (MIMO) relaying systems under general power constraints.
Beini Rong   +3 more
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla   +6 more
wiley   +1 more source

On the choice of optimality criteria in comparing statistical designs [PDF]

open access: yesCanadian Journal of Statistics, 1989
AbstractWe formulate in a reasonable sense a class of optimality functionals for comparing feasible statistical designs available in a given setup. It is desired that the optimality functionals reflect symmetric measures of the lack of information contained in the designs being compared.
K. R. Shah, B. K. Sinha
openaire   +1 more source

Re‐Irradiation in Pediatric Diffuse Midline Glioma: A Multi‐Institutional Retrospective Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with recurrent diffuse midline gliomas (DMGs) have limited therapeutic options at recurrence. Re‐irradiation (RT2) may be used at progression, but with uncertainty about the benefit. Methods We conducted a multi‐institutional retrospective study of children aged < 18 with DMG treated at three centers (Toronto, Canada ...
Ajay Thomas Alex   +13 more
wiley   +1 more source

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