Results 21 to 30 of about 121,104 (312)

Optimality criteria for futility stopping boundaries for group sequential designs with a continuous endpoint

BMC Medical Research Methodology, 2020
Background In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect ...
Xieran Li, Carolin Herrmann, Geraldine Rauch   +2 more
doaj   +1 more source

Bayesian designs for hierarchical linear models [PDF]

, 2012
Two Bayesian optimal design criteria for hierarchical linear models are discussed – the ?? criterion for the estimation of individual-level parameters ?, and the ?? criterion for the estimation of hyperparameters ?.
Allenby, Gregory, Qing Liu, Dean, Angela, Liu, Qing, Angela M. Dean, Greg M. Allenby   +5 more
core   +1 more source

Optimal designs for indirect regression [PDF]

, 2004
In many real life applications, it is impossible to observe the feature of interest directly. For example, scientists in Materials Science may be interested in detecting cracks inside objects, not visible from the outside. Similarly, non-invasive medical
Edmund Jones, G. Vitale, Osses Alvarado, Axel, Nicolai Bissantz, Vitale, Guido, Cumsille, Patricio, Takahashi, Takéo, Hajo Holzmann, Chern, I-Liang, Conca, Carlos, Preziosi, Luigi, Kavian, O., L. Preziosi, Zuo, D., Langer, Matthias, Censor, Yair, Mueller, J. L., Ambrosi, Davide Carlo, Malik, Muslim, Schwindt, Erica L., Anthony Dubois, Herrera, C. N. L., Bissantz, Nicolai, Hamilton, S. J., Horng-Shing Lu, Henry, Pierro, Álvaro Rodolfo De, Schwindt, Erica, Rosier, Lionel, Helou Neto, Elias Salomão, Muslim Malik, Marc Saillard, Cheney, Margaret, Jiang, Ming, Kawano, Alexandre, Kamal Belkebir, Dette, Holger, Alvarez, Catalina, Von Herrmann, A., Holger Dette, Monard, F., Margaret Cheney, Holzmann, Hajo, Courdurier Bettancourt, Matías, Borden, Brett, Friz, L., Pandolfi, Luciano, Chen, Tai-Been, Romero, F., Brett Borden, Stefanie Biedermann, Conca Rosende, Carlos, Munnier, Alexandre, Ortega Palma, Jaime, Jones, Edmund, Woracek, Harald, Carlos Conca, Biedermann, Stefanie, Hamilton, Sarah J., Alexandre Munnier   +58 more
core   +1 more source

Designs for generalized linear models with several variables and model uncertainty [PDF]

, 2006
Standard factorial designs may sometimes be inadequate for experiments that aim to estimate a generalized linear model, for example, for describing a binary response in terms of several variables.
D. C. Woods, Lewis, S. M., Woods, D. C., K. G. Russell, Eccleston, J. A., S. M. Lewis, J. A Eccleston, S. M Lewis, D. C Woods, K. G Russell, Russell, K. G., J. A. Eccleston   +11 more
core   +1 more source

Statistical Design and Optimization of Sustained Release Formulations of Pravastatin

Turkish Journal of Pharmaceutical Sciences, 2020
The objective of the current study was to formulate a sustained release (SR) formulation for pravastatin. Pravastatin is a lipid lowering, biopharmaceutical classification class-III agent.SR tablets of pravastatin were prepared using variable amounts of hydroxy methyl propyl cellulose (HPMC) K4M and sodium carboxy methyl cellulose in various ...
Raghavendra Kumar GUNDA, Prasada Rao MANCHINENI   +1 more
openaire   +2 more sources

A Statistical Framework for Optimal Design Matrix Generation With Application to fMRI [PDF]

IEEE Transactions on Medical Imaging, 2010
68 pages, 34 ...
Gautam V. Pendse, Richard Baumgartner, Adam J. Schwarz, Alexandre Coimbra, David Borsook, Lino Becerra   +5 more
openaire   +3 more sources

Optimal Designs For the Restricted Maximum Likelihood Estimators in a Random Split-Plot Model

Lithuanian Journal of Statistics, 2017
The design effect for the restricted maximum likelihood estimators of variance components in acompletely randomized split-plot model is studied. The model was used to represent the response generated froman experimental scenario where the whole-plot and
Oluwole Nuga, G. N. Amahia, Fatai Salami
doaj   +1 more source

Design Of Statistically Optimal Morphological Operators

, 2000
Publication in the conference proceedings of EUSIPCO, Tampere, Finland ...
Junior Barrera, Edward R. Dougherty
openaire   +3 more sources

Optimising trial designs to identify appropriate antibiotic treatment durations

BMC Medicine, 2019
Background For many infectious conditions, the optimal antibiotic course length remains unclear. The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and minimising antibiotic resistance ...
Koen B. Pouwels, Mo Yin, Christopher C. Butler, Ben S. Cooper, Sarah Wordsworth, A. Sarah Walker, Julie V. Robotham   +6 more
doaj   +1 more source

An Overview of Adaptive Designs and Some of Their Challenges, Benefits, and Innovative Applications

Journal of Medical Internet Research, 2023
Adaptive designs are increasingly developed and used to improve all phases of clinical trials and in biomedical studies in various ways to address different statistical issues.
Hongjian Zhu, Weng Kee Wong
doaj   +1 more source