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Optimization of experimental designs for biological rhythm discovery. [PDF]
PLoS Computational BiologyEqually spaced temporal sampling is the standard protocol for the study of biological rhythms. These equispaced designs perform well when calibrated to an oscillator's period, yet can introduce systematic biases when applied to rhythms of unknown ...
Turner Silverthorne +3 more
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Switching Design for Assessment of Interchangeability in Biosimilar Studies [PDF]
PharmaceuticsBackground: In biosimilar studies, assessing the switchability and interchangeability of biosimilars with their reference products is essential for ensuring reliable clinical evaluation.
Yuqing Liu, Wendy Lou, Shein-Chung Chow
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A Statistical Approach to Optimizing Concrete Mixture Design [PDF]
The Scientific World Journal, 2014 A step-by-step statistical approach is proposed to obtain optimum proportioning of concrete mixtures using the data obtained through a statistically planned experimental program. The utility of the proposed approach for optimizing the design of concrete mixture is illustrated considering a typical case in which trial mixtures were considered according ...
Shamsad Ahmad, Saeid A. Alghamdi
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Optimal Portfolio Design for Statistical Arbitrage in Finance [PDF]
2018 IEEE Statistical Signal Processing Workshop (SSP), 2018 In this paper, the optimal mean-reverting portfolio (MRP) design problem is considered, which plays an important role for the statistical arbitrage (a.k.a. pairs trading) strategy in financial markets. The target of the optimal MRP design is to construct a portfolio from the underlying assets that can exhibit a satisfactory mean reversion property and ...
Ziping Zhao 0002 +3 more
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Influence of local values on cD-optimal designs for logistic models
TecnoLógicas, 2018 When experiments are designed, it is uncommon to use criteria to determine the treatments and number of replicates that should be conducted to properly estimate the parameters in the model under study.
Víctor Ignacio López-Ríos +1 more
doaj +1 more source
Malaria Journal, 2011 Background Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not ...
Lindegardh Niklas +5 more
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Chromatin structure and context-dependent sequence features control prime editing efficiency
Frontiers in Genetics, 2023 Prime editing (PE) is a highly versatile CRISPR–Cas9 genome editing technique. The current constructs, however, have variable efficiency and may require laborious experimental optimization.
Somang Kim +15 more
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Statistical Design of Genetic Algorithms for Combinatorial Optimization Problems [PDF]
Mathematical Problems in Engineering, 2011 Many genetic algorithms (GA) have been applied to solve different NP‐complete combinatorial optimization problems so far. The striking point of using GA refers to selecting a combination of appropriate patterns in crossover, mutation, and and so forth and fine tuning of some parameters such as crossover probability, mutation probability, and and so ...
Shahsavar, Moslem +2 more
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Towards optimal design of anti-malarial pharmacokinetic studies
Malaria Journal, 2009 Background Characterization of anti-malarial drug concentration profiles is necessary to optimize dosing, and thereby optimize cure rates and reduce both toxicity and the emergence of resistance.
White Nicholas J +6 more
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BMC Medical Research Methodology, 2020 Background In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treatment effect ...
Xieran Li +2 more
doaj +1 more source