Results 61 to 70 of about 487,210 (299)

Uses and Implications of Field Disease Data for Livestock Genomic and Genetics Studies

open access: yesFrontiers in Genetics, 2012
This paper identifies issues associated with field disease data and their implications on the interpretation of estimated genetic parameters and experimental designs. The main focus is on concepts relating to the impacts of diagnostic test properties and
Steve eBishop   +2 more
doaj   +1 more source

Selection and Screening Procedures to Determine Optimal Product Designs. (REVISED, April 1997) [PDF]

open access: yes, 1996
To compare several promising product designs, manufacturers must measure their performance under multiple environmental conditions. In many applications, a product design is considered to be seriously flawed if its performance is poor under any level of
Pan, Guohua, Santner, Thomas J.
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

Optimal two-stage group sequential designs based on Mann-Whitney-Wilcoxon test.

open access: yesPLoS ONE
The Mann-Whitney-Wilcoxon test, often referred to as the Mann-Whitney U test or Wilcoxon rank-sum test, is a non-parametric statistical test used to compare two independent groups when the dependent variable is ordinal or continuous but not normally ...
Yeonhee Park
doaj   +1 more source

Springback Analysis in the Bending Process of V-shaped Stainless Steel AISI 304 Using Central Composite Design (CCD) Approach [PDF]

open access: yesE3S Web of Conferences
This study's principal goal is to investigate how the punch angle and punch radius impact the optimum springback during stainless steel sheet made of AISI 304 bent.
Nur Rusdi   +3 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Experimental Designs for Binary Data in Switching Measurements on Superconducting Josephson Junctions [PDF]

open access: yes, 2006
We study the optimal design of switching measurements of small Josephson junction circuits which operate in the macroscopic quantum tunnelling regime. Starting from the D-optimality criterion we derive the optimal design for the estimation of the unknown
Abdelbasit K. M.   +16 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Design Issues for Generalized Linear Models: A Review

open access: yes, 2006
Generalized linear models (GLMs) have been used quite effectively in the modeling of a mean response under nonstandard conditions, where discrete as well as continuous data distributions can be accommodated.
Ghosh, Malay   +3 more
core   +3 more sources

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