Results 61 to 70 of about 129,671 (267)
A Non-Parametric Sequential Procedure for the Generalized Partition Problem
MathematicsIn selection and ranking, the partitioning of treatments by comparing them to a control treatment is an important statistical problem. For over eighty years, this problem has been investigated by a number of researchers via various statistical designs to
Tumulesh K. S. Solanky, Jie Zhou
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Multi-Objective Optimal Experimental Designs for ER-fMRI Using MATLAB
Journal of Statistical Software, 2009 Designs for event-related functional magnetic resonance imaging (ER-fMRI) that helpto eciently achieve the statistical goals while taking into account the psychological con-straints and customized requirements are in great demand.
Ming-Hung Kao
doaj
Some recent developments in the design of adaptive clinical trials
Statistica, 2013 For clinical trials that compare two or more competing treatments, the literature proposes several randomization rules that aim at favouring, at each stage of the trial, the treatment that appears to be best.
Alessandro Baldi Antognini +2 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
POBE: A Computer Program for Optimal Design of Multi-Subject Blocked fMRI Experiments
Journal of Statistical Software, 2014 For functional magnetic resonance imaging (fMRI) studies, researchers can use multi-subject blocked designs to identify active brain regions for a certain stimulus type of interest.
Bärbel Maus, Gerard van Breukelen
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Известия высших учебных заведений. Поволжский регион:Технические науки, 2023 Background. Improving designs, expanding the range and increasing the production of quadrocopters are stable global trends. Progressive technical solutions, new materials, modern microelectronics are used in the designs of quadrocopters.
E.D. Kartashova
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source