Results 91 to 100 of about 1,379,735 (279)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Examining Entropic Unbalanced Optimal Transport and Sinkhorn Divergences for Spatial Forecast Verification

Meteorological Applications
An optimal transport (OT) problem seeks to find the cheapest mapping between two distributions with equal total density, given the cost of transporting density from one place to another.
Jacob J. M. Francis, Colin J. Cotter, Marion P. Mittermaier   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

scOTM: A Deep Learning Framework for Predicting Single-Cell Perturbation Responses with Large Language Models

Bioengineering
Modeling drug-induced transcriptional responses at the single-cell level is essential for advancing human healthcare, particularly in understanding disease mechanisms, assessing therapeutic efficacy, and anticipating adverse effects.
Yuchen Wang, Tianchi Lu, Xingjian Chen, Zhongyu Yao, Ka-Chun Wong   +4 more
doaj   +1 more source

Grand-Canonical Optimal Transport

Archive for Rational Mechanics and Analysis
We study a generalization of the multi-marginal optimal transport problem, which has no fixed number of marginals $N$ and is inspired of statistical mechanics. It consists in optimizing a linear combination of the costs for all the possible $N$'s, while fixing a certain linear combination of the corresponding marginals.
Simone Di Marino, Mathieu Lewin, Luca Nenna   +2 more
openaire   +4 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

A strategy for non-strictly convex transport costs and the example of ||x-y||p in R2

, 2009
This paper deals with the existence of optimal transport maps for some optimal transport problems with a convex but non strictly convex cost. We give a decomposition strategy to address this issue. As part of our strategy, we have to treat some transport
Carlier, Guillaume, De Pascale, Luigi, Santambrogio, Filippo   +2 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Long-Scale Ollivier Ricci Curvature of Graphs

Analysis and Geometry in Metric Spaces, 2019
We study the long-scale Ollivier Ricci curvature of graphs as a function of the chosen idleness. Similarly to the previous work on the short-scale case, we show that this idleness function is concave and piecewise linear with at most 3 linear parts.
Cushing D., Kamtue S.
doaj   +1 more source

Simple Unbalanced Optimal Transport

International Mathematics Research Notices
Abstract We introduce and study a simple model capturing the main features of unbalanced optimal transport. It is based on equipping the conical extension of the group of all diffeomorphisms with a natural metric, which allows a Riemannian submersion to the space of volume forms of arbitrary total mass. We describe its finite-dimensional
Khesin, Boris, Modin, Klas, Volk, Luke
openaire   +2 more sources