Results 71 to 80 of about 6,516 (216)
AxiomsWe develop a unified analytical framework that systematically connects kinetic theory, optimal transport, and entropy dissipation through the novel integration of hypocoercivity methods with geometric structures.
Cécile Barbachoux, Joseph Kouneiher
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
MathematicsIdentifying critical infrastructure in transportation networks requires metrics that can capture both the topological structure and how demand is redistributed during disruptions.
Iman Seyedi +2 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
DiffRayFlow: A Differentiable Freeform Optical Design Engine Based on Discrete Optimal Transport
PhotonicsFreeform surfaces play a critical role in complex light-field modulation. However, traditional geometric mapping and standard optimization methods are limited by computational cost and convergence instability in large-scale ray tracing and complex ...
Liang Wang +4 more
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Mathematics of Operations ResearchClassic optimal transport theory is formulated through minimizing the expected transport cost between two given distributions. We propose the framework of distorted optimal transport by minimizing a distorted expected cost, which is the cost under a nonlinear expectation.
Haiyan Liu +3 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Weakly Noncollapsed RCD Spaces with Upper Curvature Bounds
Analysis and Geometry in Metric Spaces, 2019 We show that if a CD(K, n) space (X, d, f ℋn) with n ≥ 2 has curvature bounded above by κ in the sense of Alexandrov then f is constant.
Kapovitch Vitali, Ketterer Christian
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source