Results 81 to 90 of about 6,516 (216)
Towards Optimal Transport Networks [PDF]
Journal of Systemics, Cybernetics and Informatics, 2010 Our ultimate goal is to design transportation net- works whose dynamic performance metrics (e.g. pas- senger throughput, passenger delay, and insensitivity to weather disturbances) are optimized.
Erik P. Vargo +2 more
doaj
CoRREfficient navigation in swarms often relies on the emergence of decentralized approaches that minimize traversal time or energy. Stigmergy, where agents modify a shared environment that then modifies their behavior, is a classic mechanism that can encode this strategy.
Vishaal Krishnan, L. Mahadevan
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Frontiers in PharmacologyBackgroundPopulation pharmacokinetic modeling relies on adequate covariate specification to explain interindividual variability and support model-informed precision dosing.
Nicolas Simon +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Optimal transport analysis of high-dimensional flow cytometry data in immuno-oncology
Frontiers in ImmunologyIntroductionAdvances in single-cell and spatial profiling have enabled detailed characterization of heterogeneous samples, but analyzing this data remains challenging in settings involving multiple comparisons.
Abida Sanjana Shemonti +17 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Resource Allocation via Bayesian Optimization in Wasserstein Spaces vs. Semi-Bandit Feedback
Big Data and Cognitive ComputingSequential resource allocation has long been a central problem in operations research, yet ongoing technological developments, particularly in cloud and high-performance computing and in multi-channel marketing, are giving rise to new structural ...
Antonio Candelieri +3 more
doaj +1 more source
Zeitschrift für Analysis und ihre Anwendungen, 1995 This paper deals with a modification of L. C. Young’s flow concept in application to transportation flow problems. There will be proved necessary and sufficient conditions for an optimal transport and its dual deposit problem.
openaire +3 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source